Inflarnmatory response in the central nervous systern following perinatal asphyxia
Abstract
Objectives: To examine the relation of IL-6 levels in the CSF to the severity of
hypoxic-ischemic encephalopathy (HIE) and to the outcome. Methods: Asphyxiated
term neonates were included. Cerebrospinal fluid (CSF) IL-6 was measured by a
sensitive ELISA. Results: 20 neonates were studied: 3 had no HIE, 5 had stage 1, 6 had
stage 2, and 6 had stage 3. CSF IL-6 levels (8 to 90 hours of life) were higher in
neonates with mE stage 3 (range 65 to 2250 pg/ml) when compared to neonates with
HIE stage o to 2 «2 pg/ml in 12 neonates, lO pg/ml in 1)(P<0.01). 5 neonates had
adverse outcome: 4 died, and 1 had cerebral palsy. 13 had normal outcome. CSF IL-
6 levels (10.8±6.1 months) were higher in neonates with adverse outcome (range 65 to
2250 pg/rnl) compared to neonates with favorable outcome (P<0.05).
Conclusion: IL-6 levels in the CSF are related to neonatal neurological manifestations
and to the outcome. Our results suggest that IL-6 is implicated in the pathogenesis of
neonatal hypoxic-ischemic brain damage.
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