Glut-4 and glut-l content and in vivo insulin response in muscle from undemourished and refed rats

Authors

  • E. Rubio
  • E. Escrivá
  • A. M. Pascual-Leone

Keywords:

undernutrition, transport, Refed, Insulin

Abstract

Undemourished rats undergo an increase in insulin sensitivity. When these rats are

refed ad libitum, insulin responsiveness is normalized. Since undemutrition reduces adipose

tissue, the contribution of the muscle to the increase in glucose utilization must be remarkably

increased in the food-restricted animals. GLUT -4 and GLUT -1 are the main glucose

transporters in insulin-sensitive tissues. In this study we show that GLUT-4 content in

gastrocnemius muscle from undemourished rats is not altered. However, underfeeding

induces a significant increase in GLUT-l. When restricted rats are refed ad libitum, GLUT-

4 content rernains unaltered but GLUT-l decreases, reaching the control value. Since

undemourished rats have hypoglycaemia, we can consider the changes in GLUT -1 content

as an adpatation to glucose availability. On the other hand, in order to explain the increase

in glucose uptake in the absence of changes in the GLUT -4 content we suggest that the

effect of insulin on GLUT -4 translocation could be improved in undemourished rats.

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Published

1996-12-20

How to Cite

1.
Rubio E, Escrivá E, Pascual-Leone AM. Glut-4 and glut-l content and in vivo insulin response in muscle from undemourished and refed rats. Ars Pharm [Internet]. 1996 Dec. 20 [cited 2024 May 19];37(4):957-69. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21762

Issue

Vol. 37 No. 4 (1996)

Section

Original Articles

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