Effect of dietary cholesterol in pregnant rats and their foetuses

Authors

  • M. A. Munilla
  • E. Herrera

Keywords:

Pregnancy, Cholesterol-rich diet., Plasma lipids, Placental cholesterol

Abstract

In order of studying the responsiveness to a cholesterol-rich diet during gestation,

female rats were fed with a diet supplemented or not with 2% cholesterol and 1% sodium

cholate from the day of mating, and were studied at day 20 of pregnancy. The cholesterolrich

diet enhanced the plasma levels ofboth cholesterol and triglycerides and liver concentration

of both cholesterol and triglycerides. Liver cholesterol and triglycerides were linearly

correlated to plasma levels of cholesterol and triglycerides, respectivelly. Cholesterolrich

diet also enhanced cholesterol concentration in the placenta, which was linearly

correlated to maternal plasma cholesterol levels, whereas it did not modify placental

triglyceride concentration. In spite ofthose changes in maternal plasma Iipids, the cholesterolrich

diet did not modify fetal plasma cholesterol or triglyceride levels, nor affected litter

size and fetal weight. These findings indicate the lack of placental cholesterol transfer,

suggesting that fetal cholesterol needs are fulfilled by own cholesterol synthesis.

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References

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MABUCHI, H., SAKAI, Y., WATANABE, A , HABA, T., KOIZUMI, J., TAKEDA, R.: "Normalization of low-density Iipoprotein levels and disappearance of xanthomas during pregnancy in a woman with heterozygous familial hypercholesterolemia". Metabolism (1985), 34:309-315.

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Published

1996-12-20

How to Cite

1.
Munilla MA, Herrera E. Effect of dietary cholesterol in pregnant rats and their foetuses. Ars Pharm [Internet]. 1996 Dec. 20 [cited 2024 May 19];37(4):933-4. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21756

Issue

Vol. 37 No. 4 (1996)

Section

Original Articles

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