Expresión de mRNA de receptores de retinoide X (RXRS) y receptores de T3 (T3Rs) durante el desarrollo del tejido adiposo marrón en la rata

Authors

  • S. BRUN
  • A TUCA
  • O. VIÑAS
  • M. GIRALT
  • F. VILLARROYA
  • R. IGLESIAS

Keywords:

Retinoic acid receptors, TlR, RXR, Brown adipose tissue, UncoupJing protein, Development fetal

Abstract

Tl is a transcriptional activator of the brown adipose tissue (BAT) uncoupJing

protein gene (ucp) . Retinoid X receptor (RXR) is the heterodimeric partner of Tl

receptor (T lR) in the T 1 response element (TRE) of thyroid hormone target genes.

Present study demonstrates that RXRa, RXRj3 and RXRy genes are expressed in the

developing BAT. RXRa mRNA expression was high in BAT from 18-day-old fetuses

and decreased progressively during development, whereas RXRj3 mRNA levels were

unmodified. mRNA levels of RXRy increased sharply between days 18 and 20 of fetal

Jife, in concurrence with the onset of ucp gene transcription. Concomitantly, TlR a and

~I mRNA levels were lower in 18-day-old than in 20-day-old fetuses. Our results are

compatible with the involvement of RXRs in the regulation of ucp gene transcription

by Tl during ontogeny. The highly specific pattem of expression of each RXR isoform

suggests a particular role for them in BAT ontogeny.

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References

RICQUIER, D., CASSARD-DOULCIER, A. M.: "The biochemistry of white and brown adipocytes analysed from a selection of proteins". Eur J Biochem (1993), 218: 785-796.

NEDERGAARD, J., CONNOLLY, E., CANNON, B.: "Brown adipose tissue in the marnmalian neonate". In: Brown Adipose Tissue (1986), pp 152-213, Aroold, London.

GIRALT, M., MARTÍN, l., IGLESIAS, R., VIÑAS, O. , VILLARROYA F., MAMPEL, T.: "Ontogeny and perinatal modulation of gene expression in rat brown adipose tissue". Eur J Biochem (1990), 193: 297-302

MANCHADO, C., YUBERO, P., VIÑAS, O., IGLESIAS, R., VILLARROYA, F., MAMPEL, T. , GIRALT, M. CCAAT/enhancer-binding proteins a and ~ in brown adipose tissue: evidence for a tissue-specific pattero of expression during development Biochem J (1994), 302: 695-700.

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Published

1996-12-20

How to Cite

1.
BRUN S, TUCA A, VIÑAS O, GIRALT M, VILLARROYA F, IGLESIAS R. Expresión de mRNA de receptores de retinoide X (RXRS) y receptores de T3 (T3Rs) durante el desarrollo del tejido adiposo marrón en la rata. Ars Pharm [Internet]. 1996 Dec. 20 [cited 2024 May 19];37(4):781-9. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21297

Issue

Vol. 37 No. 4 (1996)

Section

Original Articles

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