Albumin strongly activates pyruvate dehydrogenase-catalyzed reaction in rat neurons and astrocytes from primary culture

Authors

  • A. TABERNERO
  • A. MEDINA
  • L. SÁNCHEZ-ABARCA
  • J.M. MEDINA

Keywords:

Neurons, Astrocytes, Albumin, Metabolism, Calcium

Abstract

Albumin is uptaken by newborn brain from blood during the perinatal period (1).

Previous works showed that the presence of albumin activated newborn brain metabolism

(2) in both neurons and astrocytes (3). In this work, the metabolic pathways implicated

in this effect has been studied. The fate of glucose was studied using 14C-Iabeled

glucose in different carbons in the presence or in the absence of albumin as it has been

previously reported (4) . Rere we report that albumin highly activated pyruvate

dehydrogenase-catalyzed reaction. Since the tricarboxylic acid cycle was not activated

to the same extent, the efflux of carbons from the pyruvate dehydrogenase-catalyzed

reaction was strongly increased. Albumin activated the pentose phosphate shunt and the

trycarboxylic acid cycle in astrocytes but not in neurons. Our results showed that

albumin activated astrocytes metabolism by two mechanism, and one of them was

calcium-dependent.

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Published

1997-12-20

How to Cite

1.
TABERNERO A, MEDINA A, SÁNCHEZ-ABARCA L, MEDINA J. Albumin strongly activates pyruvate dehydrogenase-catalyzed reaction in rat neurons and astrocytes from primary culture. Ars Pharm [Internet]. 1997 Dec. 20 [cited 2024 May 11];37(4):771-9. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21296

Issue

Vol. 37 No. 4 (1996)

Section

Original Articles

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