Role of IGF-I1Ras in Foetal Brown Adipocytes Differentiation: a novel therrnogenic mechanism

Authors

  • M. LORENZO
  • A. M. VALVERDE
  • T. TERUEL
  • P. NAVARRO
  • M. BENITO

Keywords:

Differentiation, IGF-L, Foetal brown adipocytes

Abstract

Foetal brown adipocyte primary cultures undergo proliferation in the presence of

IGF-I and al so induce the adipogenic-program related to lipid synthesis and the thermogenicprogram

associated with the expression of the uncoupling protein. Moreover, we have

recently described an endogenous expression of IGF-I mRNA in brown adipose tissue

at day 20 of foetal development and also an increase in the IGF-I receptor mRNA

content at the end of the foetal !ife, which runs parallel to the onset of late tissue

differentiation. Thus, IGF-I, in an autocrine/paracrine fashion may be a major signal

involved in brown adipose tissue development prior to birth.

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References

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Published

1997-12-20

How to Cite

1.
LORENZO M, VALVERDE AM, TERUEL T, NAVARRO P, BENITO M. Role of IGF-I1Ras in Foetal Brown Adipocytes Differentiation: a novel therrnogenic mechanism. Ars Pharm [Internet]. 1997 Dec. 20 [cited 2024 May 19];37(4):753-60. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21294

Issue

Vol. 37 No. 4 (1996)

Section

Original Articles

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