ExtramitochondriaI pyruvate decarboxylation in rat brain

Authors

  • J. MARTÍN-BARRIENTOS
  • M. A. ALONSO
  • J.M. MEDINA

Keywords:

Brain, Pyruvate, Pyruvate decarboxylase

Abstract

On the basis of previous work on acethylcholine and lipid synthesis and results

obtained with aminotransferase inhibitors in our laboratory, we have studied a pyruvate

decarboxylase activity (PDC) (2-oxoacid carboxylyase; EC 4.1.1.1.) from rat brain

during the perinatal periodo We have found an extrarnítochondrial PDC activity similar

to described yeast PDC. That enzyme activity showed sigmoidal kinetic with pyruvate

maintaining full activity after heating at 60 OC and it also was inhibited by acetaldehyde

or glyoxylate. Therefore, that activity increased irnmediately before birth decreasing

quickly in the earIy extrauterine life and even more in the adult.

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References

HESS B., BOITEUX, A.: In: "Regulatory Functions ofBiological Membranes" (1968), pp. 149, Elsevier, Amsterdam.

LEHMAN, H., FISCHER, G., HüBNER, G., KOHNERT, K.-D., SCHELLENBERGER A.: Eur J Biochem (1973), 32: 83-87.

FARRENKOPF, B., JORDAN F. : Prot Expres Purif(1992), 3: 101-107.

KUO, D., DIKDAN, G., JORDAN F.: J Biol Chem (1986), 261: 3316-3319.

CHEN, G., JORDAN F.: Biochemistry (1984), 23: 3576-3582.

STIVERS, J., WASHABAUGH M. : Biochemistry (1993), 32: 13472-13482.

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Published

1996-12-20

How to Cite

1.
MARTÍN-BARRIENTOS J, ALONSO MA, MEDINA J. ExtramitochondriaI pyruvate decarboxylation in rat brain. Ars Pharm [Internet]. 1996 Dec. 20 [cited 2024 May 19];37(4):729-38. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21280

Issue

Vol. 37 No. 4 (1996)

Section

Original Articles

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