Leishmania infantum PSA surface antigen: a new member of the family of leucine rich repeat containing proteins

Authors

  • A. JIMÉNEZ-RUIZ
  • C. BOCETA
  • C. ALONSO

Keywords:

Leishmania infantum, Leucine rich repeats, Diagnostic, Antogenicity, Genomic organisation

Abstract

The primary structure of the PSA antigen from Leishmania infantum shows a high homology with Leishmania major PSA-2 antigen and Leishmania amazonensis GP46/M2 antigen. Aminoacid sequence anaIysis indicates that 60%  of the molecule is formed by 13 repeated motives 24-25 aminoacids in length. The consensus sequence derived from these motives shows a highly significant homology with the consensus sequence described for leucine rich repeats, which indicates that L. infantum PSA, L. major PSA-2 and L. amazonensis GP46/M2 may be included into the newly described family of leucine rich repeat containing proteins. The expressed recombinant protein and severa!. fragments expressed individually are efficiently recognized by sera from L. infantum naturally infected dogs and leishmaniasic human patients.

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Published

1997-03-20

How to Cite

1.
JIMÉNEZ-RUIZ A, BOCETA C, ALONSO C. Leishmania infantum PSA surface antigen: a new member of the family of leucine rich repeat containing proteins . Ars Pharm [Internet]. 1997 Mar. 20 [cited 2024 Jul. 22];38(2-3):295-303. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21216

Issue

Vol. 38 No. 2-3 (1997)

Section

Original Articles

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