Double regulation of Trypanosoma cruzi histone H2A gene expression

Authors

  • C. MARAÑÓN
  • M.C. López
  • C. PUERTA

Keywords:

trypanosoma cruzi, histones, gene expression, transcriptional regulation

Abstract

The histone H2A proteins of the protozoan parasite Trypanosoma cruzi are coded by two tandemly repeated genes having different sized. They are organized in two independent clusters, but located in the same chromosome. These two units are originated by adition of an insertion sequence at the 3' end of the basic unit. Two H2A polyadenilated transcripts of 1 and 0.7 Kb are transcribed. The presence of H2A messengers in the cytoplasme for H2A is specific of the replicative stages of the parasite through a transcriptional regulation. In these replicative stages the steady state level of the H2A messengers are subjected to post-transcriptional regulation, coupled to DNA replication.

Downloads

Download data is not yet available.

References

LEWIN, B.: Genes IV (1980),519-539. Wiley, N. Y.
HAYES, J. J., CLARK, D. J., WOLFFE, A. P.: Proc Natl Acad Sci USA (1991), 64:1-10.
RECHT, B., DUNN, A., OSLEY, M. A. : Mol Cell Biol (1996), 16: 2545-2553.
WELLS, D. E.: Nucleic Acids Res (1986), 14:119-149.
HENTSCHET, C. C., BIRNSTIEL, M. L.: Cell (1981) 25:301-313
MARZLUFF, W. F.: Gene expression (1992), 2:n.2, 93-97.
GALLIE, D. R, LEWlS, N. 1., MARZLUFF, W. F.: Nucleic Acid Res (1996), 24:1954-1962.
DOMINSKI, Z., SUMEREL, J., HANSON, R. J., WHITFIELD, M. L., MARZLUFF, W. F.: Nucleic Acids Symp Ser (1995), 33:234-236.
WU, R. S., BONNER, W. M.: Cell (1981), 27:321-330.
OSLEY, M. A. : Annu Rev Biochem (1991) 60:827-861.
PELTZ, S. W., ROSS, J.; Mol. CeJl. Biol. (1987) 7: 4345-4356
MARZLUFF, W. F., PANDEY, N. B.: Trends Biochem Sci (1988), 13:49-52.
HECKER, H., BETSCHART, B., BENDER, K., BURRI, M., SCHLIMME, W.: Int J Parasitol (1994), 24:809-819.
VANHAMME, L., PAYS, E.: Microbiological Reviews (June 1995),223-240.
GARCtA-SALCEDO, J. A., OLIVER, J. L., STOCK, R. P., GONZÁLEZ, A.: Mol Microb (1994) 13(6):1033-1043.
GENSKE, J. E., CAIRNS, B. R., STACK, S. P., LANDFEAR, S. M.: Mol Cell Biol (1991), 11:240-249.
SOTO, M., REQUENA, J. M., QUIJADA, L., ALONSO, C.: Biochem J (1996 ), 318:813-819.
PUERTA, C., MARTÍN, J., ALONSO, C., LÓPEZ, M. C.: Mol and Biochem Parasitol (1994), 64: 1-10.
VÁZQUEZ, M. P., SCHIJMAN, A. G., LEVIN, M. J.: Mol and Biochem Parasitol (1994 ), 64:327-336.

Downloads

Published

1997-03-20

How to Cite

1.
MARAÑÓN C, López M, PUERTA C. Double regulation of Trypanosoma cruzi histone H2A gene expression . Ars Pharm [Internet]. 1997 Mar. 20 [cited 2024 Jul. 22];38(2-3):229-35. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21156

Issue

Vol. 38 No. 2-3 (1997)

Section

Original Articles

License

The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:

  1. The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.

b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.

c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).