Screening of avocado oil nanoformulations intended to skin delivery

Authors

  • Júlia Scherer Santos University of Santa Cruz do Sul, Santa Cruz do Sul, Brazil.
  • Júlia Cristina Koppe de Conto University of Santa Cruz do Sul, Santa Cruz do Sul, Brazil.
  • Chana Medeiros da Silva University of Santa Cruz do Sul, Santa Cruz do Sul, Brazil.
  • Rosana de Cassia de Souza Scheneider University of Santa Cruz do Sul, Santa Cruz do Sul, Brazil.
  • Claudia Regina Müller University of Santa Cruz do Sul, Santa Cruz do Sul, Brazil.

Keywords:

drug delivery systems, nanoparticles, plant oil, avocado

Abstract

Introduction: vegetable ingredients are increasingly common in skin products. Avocado oil is an ingredient of natural source with various properties on skin. In this work crude avocado oil-loaded nanocapsules were evaluated regarding to its physicochemical stability to obtain a skin delivery formulation with adequate quality.

Method: nanoparticles formulations with components variation were evaluated for 2 months. Nanoparticle formulation considered the most stable was further evaluated for 6 months. Furthermore, oxidative stability of nanoencapsulated avocado oil and crude avocado oil was also performed in order to detect any sign of oil oxidation.

Results: all formulations had negative zeta potential after 2 months of storage. pH values of nanoparticles ​​remained stable throughout the test. Formulation with the lowest content of ingredients exhibited the highest stability after 2 months of storage. Nanoencapsulated avocado oil and crude avocado oil showed no evidence of oxidation.

Conclusions: Aqueous dispersions with the lowest content of ingredients presented the best physicochemical stability. Therefore, we have demonstrated preliminary the feasibility of developing avocado-oil loaded nanocapsules.

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Author Biography

Júlia Scherer Santos, University of Santa Cruz do Sul, Santa Cruz do Sul, Brazil.

Pharmaceutical development

Cosmetology

Nanotechnology

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Published

2020-12-20

How to Cite

1.
Scherer Santos J, Koppe de Conto JC, Medeiros da Silva C, de Cassia de Souza Scheneider R, Müller CR. Screening of avocado oil nanoformulations intended to skin delivery. Ars Pharm [Internet]. 2020 Dec. 20 [cited 2025 Jul. 28];62(1):66-74. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/15486

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Original Articles