Characterization of liquid crystals with Miconazole in biphasic systems by polarized microscopy
DOI:
https://doi.org/10.30827/ars.v61i3.10268Keywords:
Miconazole, emulsions, liquid crystalsAbstract
Introduction: emulsions are a type of pharmaceutical preparation widely used in topical applicationsconsisting of two-phase systems of oil-in-water or water-in-oil, where the desired active ingredient is incorporatedinto one of the phases depending on its solubility. Several studies show that stability is greaterin emulsions with liquid-crystalline structures. The liposoluble active substance Miconazole, whichacts as an antifungal agent, is solubilized in the oil phase of the emulsion as well as in the fraction of thehydrocarbon chain in liquid crystals.
Method: microscopic techniques were used to analyze the characteristics of both a conventional emulsionand another one containing the liquid crystals. Miconazole was incorporated into both emulsions;drop dimensions in the internal phase were determined and the liquid crystals were characterized bypolarization microscopy.
Results: through the analysis of the microscopic images of the formulation with liquid crystals withMiconazole and without Miconazole, it was possible to determine that approximately 80% of the dropshave dimensions ranging from 0.5μm - 1μm. Microscopic observations with polarized light allowed usto determine that liquid crystals have birefringence with the formation of negative uniaxial extinctioncrosses, which are characteristic of laminar lyotropic phases with focal conical textures.
Conclusions: the results show that the addition of Miconazole doesnot interfere with the formation of the structure of the liquid crystals.Therefore, the formation of liquid crystals depends both onthe components of the formulation and the preparation technique.
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