Contenido principal del artículo

Katakam Prakash
Faculty of Pharmacy, 7th of April University, Al-Zawia (Libya)
Libia
Bahlul Z Awen
Faculty of Pharmacy, 7th of April University, Al-Zawia (Libya)
Libia
Chandu B Rao
Faculty of Pharmacy, 7th of April University, Al-Zawia (Libya)
Libia
Adiki S Kumari
Faculty of Pharmacy, 7th of April University, Al-Zawia (Libya)
Libia
Vol. 53 Núm. 3 (2012), Artículos de revisión, Páginas 26-33
Recibido: Apr 17, 2016 Publicado: Sep 20, 2012
Derechos de autor Cómo citar

Resumen

Objetivos: Elaborar y evaluar tiras subgingivales combinadas compuestas por Ofloxacino y metronidazol in vitro con alginato de calcio biodegradable.

Métodos: las tiras se prepararon utilizando el método de evaporación del disolvente. Se usó una concentración del 10% de CaCl2 para la gelificación.de las tiras.

Resultados: el grosor de las tiras se encuentra dentro de las recomendaciones (>320 μm). In vitro, la liberación de la droga siguió una cinética bifásica que fue suficiente para alcanzar la CMI e inhibir el crecimiento de microorganismos durante 5 días. La “tasa de liberación de la droga” es inversamente proporcional a la concentración de polímero de la formulación. La liberación de la “droga” fue por difusión y en segunda fase por disolución.

Discusión: Las preparaciones OM1 y OM2 que contienen un 90 y un 75% de polímero respectivamente, podrían ser empleadas en liberación controlada durante cinco días en infecciones sublinguales. Siendo el alginato cálcico biodegradable una buena elección como polímero retardante

Descargas

La descarga de datos todavía no está disponible.

Detalles del artículo

Citas

Goodson JM. Antimicrobial strategies for treatment of periodontal diseases. Periodontol. 1994; 5: 142-168.

Academy Report. American academy of periodontology, position paper. Systemic antibiotics in periodontics. J Periodont. 2004; 75: 1553–65.

Goodson JM, Offenbacher S, Farr DH, Hogan PE. Periodontal disease treatment by local drug delivery. J Periodont. 1985; 56: 265-72.

Elkayam R, Friedman M, Stabholz A, Soskolne AW, Azoury R. Sustained release device of tetracycline for dental use, structure and kinetics of drug release in vitro and in vivo. Proc Int Conf Pharm Tech. 1989; 2: 346–54.

Stabholz A, Soskolne WA, Friedman M, Sela MN. The use of sustained release delivery of chlorhexidine for the maintenance of periodontal pockets: 2 year clinical trial. J Periodont. 1991; 62: 429–33.

Stoltze K. Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel. J Clin Perio. 1992; 19: 698–701.

Okuda K, Wolff L, Oliver R, Osborn J, Stoltenberg J, Bereuter J. Minocycline slow release formulation effect on subgingival bacteria. J Periodont. 1992; 63 (2):73–9.

Medlicott NJ, Jones DS, Tucker IG, Holborow D. Preliminary release studies of chlorhexidine (base and diacetate) from poly (gecaprolactone) films prepared by solvent evaporation. Int J Pharm. 1992; 84: 85–89.

Norling T, Lading P, Engstrom S, Larsson K, Krog N, Nissen SS. Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease. J Clin Perio. 1992; 19: 687–92.

Minabe M, Uematsu A, Nishijima K, Tomomatsu E, Tamura T, Hori T. Application of a local drug delivery system to periodontal therapy: 1. Developement of collagen preparations with immobilized tetracycline. J Periodont. 1989; 60: 113–7.

Chung TW, Yang J, Akaike T, Cho KY, Nah JW, Kim SI et al. Preparation of alginate/galactosylated chitosan scaffold for hepatocyte attachment. Biomaterials. 2002; 23: 2827–34.

Raymond CR, Paul JS, Marian EQ. Handbook of Pharmaceutical Excipients. 6ª ed. London: Pharmaceutical Press; 2009. 917.

Pluta J, Haznar D. Properties and active substance release kinetics from gelatin-alginate matrices. Polim Med. 2006; 36:55–69.

Boateng JS, Auffret AD, Matthews KH, Humphrey MJ, Stevens HN, Eccleston GM. Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces. Int J Pharm. 2010; 389:24–31.

Satishbabu BK, Srinivasan BP. Preparation and evaluation of buccoadhesive films of atenolol. J Pharm Sci. 2008; 70:175-9.

Trezubov VN, Kobzev SA, Lobanov SA, Akulovich AV. The use of new biologically compatible materials in the combined treatment of periodontal diseases. Stomatologiia (Mosk). 1996; 75:59–61.

Steve WNU, Mel SL, Song-Shu L, Err-Cheng C, Shih-Jung L. Development of a biodegradable alginate carrier system for antibiotics and bone cells. J Ortho Res. 2006; 25:62–72.

Bahlul ZA, Prakash K, Chandu BR, Soad AM, Turkiya OA. Design and in-vitro evaluation of controlled release cephalexin subgingival films using natural biodegradable polymer. Rec Res Sci Tech. 2010; 2:6–11.

The United States Pharmacopoeia 30-National Formulary 25. Rockville, MD: United States Pharmacopoeial Convention; 2007. p 2653.

Steven G, Judith AO. Anti-infectives In: Lippincott Williams and Wilkins, editors. Remington: The Science and Practice of Pharmacy. 21ª ed. Philadelphia: Lippincott Williams and Wilkins. 2005: p. 1658-9.

Antonio DD, Piccotomini R, Lacone A, Fioritoni G, Pamiti G, Betti S et al. Comparison of ciprofloxacin, ofloxacin and pefloxacin for the prevention of the bacterial infection in neutropenic patients with haematological malignancies. J Antimicrob Chemother. 1994; 33:837–41.

Kimura S, Toda H, Shimabukuro Y, Kitamura M, Fujimoto N, Miki Y. Topical chemotherapy in human periodontitis using a new controlled-release insert containing ofloxacin. I. Microbiological observation. J Periodontal Res. 1991; 26(1):33–41.

Higashi K, Morisaki K, Hayashi S, Kitamura M, Fujimoto N, Kimura A, et al. Local ofloxacin delivery using a controlled-release insert (PT-01) in the human periodontal pocket. J Periodontal Res. 1990; 25:1–5.

The United States Pharmacopoeia 30-National Formulary 25. Rockville, MD: United States Pharmacopoeial Convention; 2007. p 2653.

Margaret A, Phillips SL, Stanley JR. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Laurence LB, editor. Goodman & Gilman's: the pharmacologic basis of therapeutics. New York: McGraw-Hill Professional. 11th ed. 2006. P. 1658.

Wright TL, Ellen RP, Lacroix JM, Sinnadurai S, Mittelman MW. Effects of metronidazole on Porphyromonas gingivalis biofilms. J Periodon Res. 1997; 32:473–7.

Shifrovitch Y, Binderman I, Bahar H, Berdicevsky I, Zilberman M. Metronidazole-loaded bioabsorbable films as local antibacterial treatment of infected periodontal pockets. J Periodontol. 2009; 80:330–7.

El-Kamel AH, Ashri LY, Alsarra IA. Micromatricial metronidazole benzoate strip as a local mucoadhesive delivery system for treatment of periodontal diseases. AAPS PharmSciTech. 2007; 8:E75.

Bickel M, Munoz JL, Giovannini P. Acid-base properties of human gingival crevicular fluid. J Dent Res. 1995; 64: 1218–20.

Divya PV, Nandakumar K. Local Drug Delivery-Periocol in Periodontics. Trends Biomater Artif Organs. 2006; 19:74-80.

Ellie JCG, Diane MC. Comparative activity of ciprofloxacin, ofloxacin, sparfloxacin, temafloxacin, CI-960, CI-990, and WIN 57273 against anaerobic bacteria. Antimicrob Agents Chemother. 1992; 36: 1158-62.