Assessment of the Risk of Atherogenicity and Cardiometabolic Health in Type II Diabetes Mellitus

Suhaer Zeki Al-Fadhel; Nibras H. Abdulsada; Shaden M H Mubarak

doi:10.30827/ars.v66i4.32268

Autores/as

Suhaer Zeki Al-Fadhel University of Kufa, College of Pharmacy, Department of Clinical Laboratory Science
Nibras H. Abdulsada University of Kufa, College of Pharmacy, Department of Physiology
Shaden M H Mubarak University of Kufa, College of Pharmacy, Department of Clinical Laboratory Science

DOI:

https://doi.org/10.30827/ars.v66i4.32268

Palabras clave:

Diabetes; Índice aterogénico; Perfil lipídico; azúcar en la sangre

Resumen

Introducción: La diabetes mellitus es un trastorno metabólico caracterizado por niveles persistentemente elevados de glucosa en sangre y diversos grados de alteración en el metabolismo de proteínas, lípidos e hidratos de carbono. Existe un aumento de mortalidad súbita que varía entre uno y cinco veces, además de un alto riesgo de desarrollar múltiples enfermedades, incluida la enfermedad cardiovascular, que comprende enfermedad arterial coronaria, infarto de miocardio, insuficiencia cardíaca congestiva y enfermedad vascular periférica. Un nuevo parámetro para evaluar el riesgo aterogénico y la salud cardiometabólica es el índice aterogénico del plasma, que corresponde a la relación entre los triglicéridos y el colesterol de las lipoproteínas de alta densidad, transformada logarítmicamente.

Método: El presente estudio de casos y controles incluyó a 30 hombres con diabetes tipo 2 (T2DM) que no utilizaban medicamentos hipolipemiantes y 25 hombres aparentemente sanos coo grupo control. Tras un ayuno nocturno de al menos 8 horas, se tomaron muestras de sangre de cada participante y se analizaron para evaluar la glucosa en sangre en ayunas, la hemoglobina A1c y el perfil lipídico (lipoproteína de baja densidad, lipoproteína de alta densidad, colesterol total y triglicéridos).

Resultados: La comparación entre el grupo T2DM y el grupo control reveló que las edades eran similares, pero que todos los factores estudiados mostraron diferencias significativas entre ambos grupos (p≤0,05), excepto la presión arterial diastólica. Además, se observó una fuerte correlación entre el perfil lipídico y el índice aterogénico del plasma.

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