Citrus Flavonones into nanotechnology-based formulations to skin treatment

Júlia Scherer Santos; Mateus Pereira Gonzatto

doi:10.30827/ars.v65i1.29433

Autores/as

Júlia Scherer Santos Federal University of Juiz de Fora https://orcid.org/0000-0002-7441-1940
Mateus Pereira Gonzatto Department of Agronomy, Federal University of Viçosa, Viçosa https://orcid.org/0000-0001-6394-2802

DOI:

https://doi.org/10.30827/ars.v65i1.29433

Palabras clave:

sistemas de liberación de fármacos; nanopartículas; flavonoides; Citrus

Resumen

Introducción: Las flavononas muestran una aplicación potencial en el tratamiento de trastornos de la piel, cuyo rendimiento puede mejorarse mediante el uso de nanoportadores lipídicos y poliméricos. En esta revisión, se analiza un enfoque reciente con respecto a los nano-portadores que contienen naringina, naringenina, hesperidian o hesperitina para aplicación cutánea.

Método: Esta revisión aborda las publicaciones de los últimos 6 años sobre nanosistemas que contienen flavononas cítricas para aplicaciones cutáneas. Los artículos se seleccionaron mediante la búsqueda en base de datos Scopus de nanosistemas que contienen hesperidina, hesperitina, naringina o naringenina para aplicación cutánea, artículos de investigación escritos en inglés y publicados entre 2018 y 2023, y abordando la penetración de la piel o evaluación biológica.

Resultados: La mayoría de los artículos emplearon sistemas lipídicos como nano-portadores. La naringenina fue la flavonona más utilizada. En relación con los beneficios para la piel, se destacan la mejora de la cicatrización de heridas, el tratamiento de la dermatitis atópica y las enfermedades relacionadas con el estrés oxidativo. A pesar de los probables beneficios, el desarrollo de nanomedicinas de origen vegetal es complejo, lo que impone limitaciones al desarrollo de nuevos productos farmacéuticos. Además, se han demostrado el potencial de las flavononas en el tratamiento del cáncer de piel.

Conclusiones: Se emplean portadores lipídicos, poliméricos y nanohíbridos para administrar flavanonas. Debido a sus actividades antioxidantes y antiinflamatorias, las flavanonas tienen aplicaciones potenciales en el tratamiento de diferentes trastornos de la piel. Por lo tanto, existe una aplicación prometedora de las flavanonas para mejorar la salud humana, principalmente con su carga en nanoportadores.

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Biografía del autor/a

Júlia Scherer Santos, Federal University of Juiz de Fora

Pharmacist. PhD in Pharmaceutical Nanotechology. Specialist in Cosmetology. Experience as professor. I work in the following areas: nanotechnology, cosmetic, aesthetics.

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