Rápida desintegración de tabletas de clorhidrato de metoclopramida utilizando novela de celulosa químicamente modificada
Palabras clave:
Chemically modified cellulose, Microcrystalline cellulose, Metoclopramide hydrochloride, Rapidly disintegrating tablets, SuperdisintegrantResumen
The purpose of the study was to modify cellulose using hydrochloride salt of 2-aminoethanoyl chloride with optimum hydrophilic and hydrophobic properties to impart it a superdisintegrant activity and also to formulate and evaluate rapidly disintegrating tablets of metoclopramide hydrochloride using this novel chemically modified cellulose. A novel polymer, chemically modified cellulose was synthesized by chemically modifying microcrystalline cellulose with hydrochloride salt of 2-aminoethanoyl chloride. The formation of novel polymer was confirmed by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy and by differential scanning calorimetric (DSC) and elemental analysis. The toxicity study proved the novel modified cellulose to be non toxic. Rapidly disintegrating tablets of metoclopramide hydrochloride were prepared using novel modified cellulose and compared for the release of drug with control formulation, prepared using non modified microcrystalline cellulose. The tests like wetting time, water absorption ratio and in vitro disintegration time were carried out to elucidate the relationship between them. The study revealed that novel modified cellulose in a concentration of 2% released the drug faster than at a concentration higher than that. Hence it could be concluded that microcrystalline cellulose, a polymer which is devoid of superdisintegrant activity, can suitably be modified by controlled chemical modification of it with hydrochloride salt of 2-aminoethanoyl chloride or similar groups with optimum hydrophilicity and hydrophobicity to convert it into a superdisintegrant material. It can also be concluded that rapidly disintegrating tablets of metoclopramide hydrochloride can suitably be developed for the efficient management of emesis.Descargas
Citas
Hirani J, Rathod D, Vadalia K. Orally disintegrating tablets: a
review. Trop J Pharm Res. 2009; 8(2):161-172.
Seager H. Drug delivery products and the zydis fast dissolving dosage. J Pharm Pharmacol.1998; 50: 375-382.
Dobetti L. Fast melting tablets: developments and technologies. Pharm Technol Drug Deliv.2001:44-50.
Shastry S, Nyshadham J, Fix J. Recent technological advances in oral drug delivery: a review. Pharm Sci Technol Today.2000:138-145.
Abdelbary G, Prinderre P, Eouani C, Joachim J, Reynier J, Piccerelle P. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int J Pharm. 2004; 278:423-433.
Desai S, Kharade S, Petkar K, Kuchekar B. Optimizing orodissolving tablets of desloratidine by superdisintegrants. The Ind Pharmacist. 2007; 10:83-86.
Koushik D, Dureja H, Saini T. Mouth dissolving tablets: a review. Ind drugs. 2004; 41:187-193.
Cheu P, Welch R, Binder C. Acceptability and disintegration rates of orally disintegrating resperidone tablets in patients with schizophrenia or schizoaffective disorders. Can J Psychiatry. 2004; 50:193-198.
Shu T, Suzuki H, Hironaka K, Ito K. Studies on rapidly disintegrating tablets in oral cavity using coground mixture of mannitol with crosspovidone. Chem Pharm Bull (Tokyo). 2002; 50: 193-198.
Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolving tablets of Nimesulide using vacuum drying technique. AAPS Pharmscitech. 2004; 5: E36.
Chang R, Guo X, Burnside B, Couch R. Fast dissolving tablets. Pharm technol. 2000; 24: 52-58.
Shimizu T, Sugaya M, Nakano Y. Formulation study for lansoprazole fast disintegrating tablets III: design of rapidly disintegrating tablets. Chem Pharm Bull (Tokyo).2003; 51: 121-127.
Khan S, Kataria P, Nakhat P, Yeole P. Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid disintegrating tablets. AAPS Pharmscitech. 2007; 8(2), E1-E7.
Fu Y, Jeong S, Park K. Fast melting tablets based on highly plastic granules. J control Rel. 2005; 109:203-210.
Watanabe A, Hanawa T, Sugihara M, Yamamoto K. Release profiles of phenytoin from new oral dosage form for the elderly. Chem Pharm Bull (Tokyo). 1994; 42: 642-645.
Fu Y, Yang S, Jeong S, Kimamura S, Park K. Orally fast disintegrating tablets: developments, technologies, taste masking and clinical studies. Crit Rev Ther Drug Carrier Syst. 2004; 21: 64-72.
Sugimoto Y, Maejima T, Narisawa S, Matsubara K, Yoshino H. Factors affecting the characteristics of rapidly disintegrating tablets in the mouth prepared by the crystalline transition of amorphous sucrose. Int J Pharm. 2005; 296:64-72.
Abdelbary G, Eouani C, Prinderre P, Joachim J, Reynier J, Piccerelle P. Determination of the in vitro disintegration profile of rapidly disintegrating tablets and correlation with oral disintegration. Int J Pharm. 2005; 292:29-41.
Harada T, Narazaki R, Nagira S, Ohwaki T, Aoki S, Iwamoto K. Evaluation of the disintegration properties of commercial famotidine 20 mg orally disintegrating tablets using a simple new test and human sensory test. Chem Pharm Bull (Tokyo). 2006; 54: 1072-1075.
Zakia, N, Awad, G, Mortada, N, Seham S. Enhanced bioavilability of metoclopramide hydrochloride by intranasal administration of a mucoadhesive in situ gel with modulated rheological and mucocilliary transport properties. Eur. J. Pharm. Sci. 2007; 32: 296-307.
Dollery, C, Therapeutic Drugs. 2nd ed. London : Churchill Livingstone; 1999.
Hasan E, Amro B, Arafat T, Badwan, A.Assessment of controlled release hydrophilic matrix formulation of metoclopramide hydrochloride. Eur. J. Pharm. Biopharm. 2003; 55: 339-344.
Rowe, R., Handbook of Pharmaceutical Excipients, 4th ed., Pharmaceutical Press, London, (2003).
Morita Y, Tsushima Y, Termoz R, Ajioka J, Takayama K. Evaluation of disintegration time of rapidly disintegrating tablets via a novel method using a CCD camera. Chem Pharm Bull (Tokyo).2002; 50:1181-1186.
Watanabe Y, Yamamoti Y, Fujii M, Kondoh M, Shibata Y. A novel method for predicting disintegration time in the mouth of rapid disintegrating tablet by compaction analysis using Tab AII. Chem Pharm Bull (Tokyo).2004; 52: 1394-1395.
Narazaki R, Harada T, Takami N, Koto Y, Ohwaki T. A new method for disintegration studies of rapid disintegrating tablets. Chem Pharm Bull (Tokyo).2004; 52:704-707.
Swamy P, Arefulla S, Shirsand S, Gandra S., Prashanth B. Orodispersible tablets of meloxicam using disintegrant blends for improved efficacy. Ind. J. Pharm. Sci. 2007; 69 (6): 836-840.
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Los artículos que se publican en esta revista están sujetos a los siguientes términos en relación a los derechos patrimoniales o de explotación:
- Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, la cual se distribuirá con una licencia Creative Commons BY-NC-SA 4.0 que permite a terceros reutilizar la obra siempre que se indique su autor, se cite la fuente original y no se haga un uso comercial de la misma.
- Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la fuente original de su publicación.
- Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en repositorios institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).
