Farmacología de productos naturales: un enfoque reciente en Calotropis gigantea y Calotropis procera

Autores/as

  • Shripad M. Bairagi Research Scholar, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India Department of Pharmacology, MES’s College of Pharmacy, Sonai, Ahmednagar, Maharashtra, India
  • Prashant Ghule Research Scholar, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India Department of Pharmacology, MES’s College of Pharmacy, Sonai, Ahmednagar, Maharashtra, India
  • Rit Gilhotra Principal, School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.30827/ars.v59i1.7276

Palabras clave:

Calotropis gigantea, Calotropis procera, Farmacognosia, Farmacología

Resumen

Introducción: Desde la antigüedad, las personas han utilizado plantas medicinales para tratar diversas enfermedades. Las plantas medicinales son la fuente importante de los fármacos, y muchas de ellas, que están actualmente disponibles en el mercado farmacéutico, se obtienen de fuentes vegetales. Calotropis gigantea y Calotropis procera son arbustos pequeños que se utilizan convencionalmente para tratar muchas enfermedades como el cáncer, la diabetes y las enfermedades intestinales en países africanos y asiáticos. Siempre se ha prestado una mayor atención a la Atención Primaria de salud: la atención básica de la salud es eficaz y asequible para los países en desarrollo.

Objetivos:

Este trabajo tiene como objetivo revisar las características farmacológicas y farmacognosóticas de Calotropis gigantea y Calotropis procera.

Método: Breve revisión de la literatura reciente realizada utilizando Scopus, Google scholar.

Resultado y discusión: Varios estudios proporcionan evidencia de sus propiedades antioxidantes, analgésicas, antiinflamatorias, antidiarreicas, anticonvulsivas, antipalúdicas, hepatoprotectoras, antitumorales, antimicrobianas y anti-nociceptivas.

Conclusión: Especies de Calotropis no ampliamente reconocido mostraron diferentes acciones farmacológicas, debido a la presencia de metabolitos secundarios efectivos.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Kiritikar K, Basu B. Indian Medicinal Plants. Int B Distrib. 1987;III(2 Edn):1432–6.

Bairagi SM, Aher AA, Nema N, Pathan IB. Evaluation of anti-diarrhoeal activity of the leaves extract of Ficus Microcarpa L. (Moraceae). Marmara Pharmaceutical Journal. 2014;3(18):135-135. Doi:10.12991/mpj.2014187240

Rahimi M. Pharmacognostical Aspects and Pharmacological activities of Calotropis procera. Bulletin of Environment, Pharmacology and Life Sciences. 2015;4(2):156-162.

Nalwaya N, Pokharna G, Deb L, Jain NK. Wound healing activity of latex of Calotropis gigantea. International Journal of Pharmacy and Pharmaceutical Sciences. 2009;(1):176–81.

Arya S, Kumar VL. Antiinflammatory efficacy of extracts of latex of Calotropis procera against different mediators of inflammation. Mediators of Inflammation. 2005;2005(4):228–32. Doi:10.1155/MI.2005.228

Verma VN. The chemical study of Calotropis. International Letters of Chemistry, Physics and Astronomy. 2014;1:74-90. 10.18052/www.scipress.com/ILCPA.20.74

Oloumi H. Phytochemistry and Ethno-Pharmaceutics of Calotropis procera. Ethno-Pharmaceutical Products. 2014;1(2):1–8.

Joseph B, George J, Jeevitha M V, Charles S. Pharmacological and biological overview on Calotropis gigantea: a comprehensive review. International Research Journal Pharmaceutical and Applied Sciences [Internet]. 2013;3(5):219-223, 5 . Available from: http://www.irjpas.com/zip.php?file=File_Folder/IRJPAS 3(5)219-223.pdf&id=308&quat=3

Sharma AK, Kharb R, Kaur R. Pharmacognostical aspects of Calotropis procera (Ait.) R. Br. International Journal of Pharma and Bio Sciences. 2011;2(3):480–8.

Parihar G, Sharma A, Ghule S, Sharma P, Deshmukh P, Srivastava DN. Anti inflammatory effect of Calotropis procera root bark extract . Asian Journal of Pharmacy and Life Science. 2011;1(1):29–44.

Evans WC. Trease and Evans’ Pharmacognosy.2005:41-47.

Habib MR, Karim MR. Antimicrobial and Cytotoxic Activity of Di-(2-ethylhexyl) Phthalate and Anhydrosophoradiol- 3-acetate Isolated from Calotropis gigantea (Linn.) Flower. Korean Society of Mycology. 2009;37(1):31–6.

Radhakrishnan K, Thangamani P, Balakrishnan V. Antibacterial and phytochemical analysis of stem and root extracts of Calotropis gigantea against selected pathogens. Malaya Journal of Biosciences. 2014;1(1):49–55. Available from: http://www.malayabiosciences.com/download.php?id=10

Mohamed NH, Ismail MA, Abdel-Mageed WM, Mohamed Shoreit AA. Antimicrobial activity of latex silver nanoparticles using Calotropis procera. Asian Pacific Journal of Tropical Biomedicine . 2014;4(11):876–83. Doi:10.12980/APJTB.4.201414B216, Available from: http://linkinghub.elsevier.com/retrieve/pii/S2221169115300344

Kumar VL, Basu N. Anti-inflammatory activity of the latex of Calotropis procera. Journal of Ethnopharmacology. 1994;44(2):123–5.

Rahman R, Rahman F, Shashank B, Rajasshekar S, Gangadhar B, Chandrashekhar S, Evaluation of Calotropis Gigantea root in experimental diarrhoea. International Journal of Pharmacy & Industrial Research. 2012; 2(1):10-15.

Murti Y, Singh SP, Devender P. Comparison of anti-diarrheal activity of hydroethanolic extract of Calotropis Procera and Calotropis Gigantea leaves. Journal ofPharmaceutical and Scientific Innovation. 2012 ;1(4):32-33.

Lodhi G, Singh HK, Pant KK, Hussain Z. Hepatoprotective effects of Calotropis gigantea extract against carbon tetrachloride induced liver injury in rats. Acta Pharmaceutica. 2009;59(1):89–96. Doi: 10.2478/v10007-009-0002-2.

Ramachandra Setty S, Quereshi AA, Viswanath Swamy AHM, Patil T, Prakash T, Prabhu K, et al.. Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats. Fitoterapia. 2007;78(7–8):451–4. Doi:10.1016/j.fitote.2006.11.022

Sayed AELD, Mohamed NH, Ismail MA, Abdel-Mageed WM, Shoreit AAM. Antioxidant and antiapoptotic activities of Calotropis procera latex on Catfish (Clarias gariepinus) exposed to toxic 4-nonylphenol. Ecotoxicology and Environmental Safety. 2016;128:189–94. Doi: 10.1016/j.ecoenv.2016.02.023

Habib MR, Karim MR. Effect of anhydrosophoradiol-3-acetate of Calotropis gigantea (Linn.) flower as antitumoric agent against Ehrlich’s ascites carcinoma in mice, Pharmacological Reports. 2013; 65: 761-767.

Habib MR, Karim MR. Evaluation of antitumour activity of Calotropis gigantea L. root bark against Ehrlich ascites carcinoma in Swiss albino mice. Asian Pacific Journal of Tropical Medicine. 2011;4(10):786–90. Doi:10.1016/S1995-7645(11)60194-6.

Mathur R, Gupta SK, Mathur SR, Velpandian T. Anti-tumor studies with extracts of Calotropis procera (Ait.) R.Br. root employing Hep2 cells and their possible mechanism of action. Indian Journal of Experimental Biology. 2009;47(5):343–8.

Iqbal Z, Lateef M, Jabbar A, Muhammad G, Khan MN. Anthelmintic activity of Calotropis procera (Ait.) Ait. F. flowers in sheep. Journal of Ethnopharmacology. 2005;102(2):256–61. Doi: 10.1016/j.jep.2005.06.022

Dongare SD, Mali SS, Dhanawade PP, Patrekar PV. In-vitro anthelmintic activity of Calotropis Gigantea against Indian earth worm Pheretima Posthuma. International Journal of Institutional Pharmacy and Life Sciences.2015;5(1):117-123.

Singh K, Rao V, Hussain Z, Pahuja. Evaluation of anti-diabetic and antioxidant activity of extract of Calotropis Gigantea linn in streptozotocin induced diabetic rats. The Pharma Innovation. 2014; 2(11):1-12.

Mário C.L. Neto, Carlos F. B. de Vasconcelos, Valerium N. Thijan, Germana F. R. Caldas, Alice V. Araujo, Joao H. Costa-Silva. Evaluation of antihyperglycaemic activity of Calotropis Procera leaves extract on streptozotocin-induced diabetes in wistar rats. Revista Brasileira Farmacognosia. 2013;23:913-919. Doi: 10.1590/S0102-695X2013000600008.

Tour NS, Talele GS. Gastric antiulcer and anti-inflammatory activities of Calotropis Procera stem bark. Revista Brasileira Farmacognosia Brazilian Journal Pharmacognosy. 2011;21(6): 1118-1126. Doi:10.1590/S0102- 695X2011005000175.

Kshirsagar A. Patil PA, Purnima A, Hulkoti B. Anti-inflammatory and anti-ulcer effects of Calotropis Gigantea R. Br. Flowers on rodent. Journal of Natural Remedies. 2008; 8(2):183-190. Doi:10.18311/jnr/2008/332

Raquel Cristina de Sousa Lima , Márcia Calheiros Chaves Silva , Carlos Clayton Torres Aguiar, Edna Maria Camelo Chaves, Katia Cilene Ferreira Dias, Danielle Silveira Macedo. Anticonvulsant action of Calotropis procera latex proteins. Epilepsy & Behavior. 2012; 23: 123–126. Doi:10.1016/j.yebeh.2011.11.008

Ghule SD, Vidyasagar G, Bhandari A, Sharma P, Gunjal AP. CNS activity of leaves extract of Calotropis gigantea. Asian Pacific Journal of Tropical Disease. 2014;4(S2):S902–5. Doi:10.1016/S2222-1808(14)60755-6

Mudi SY, Bukar A. Anti-plasmodia activity of leaf extract of Calotropis Procera linn. Biokemostri, Nigeria. 2011;23(1):29-34.

Dhivya R, Manimegalai K, Mosquito repellent activity of Calotropis gigantea (Apocynaceae) flower extracts against the filarial vector Culex Quinquefasciatus. Hygeia:Journal For Drugs And Medicine. 2013; 5 (2): 56-62.

Deshmukh PT, Fernandes J, Atul A, Toppo E. Wound healing activity of Calotropis gigantea root bark in rats. Journal of Ethnopharmacology. 2009;125(1):178–81. Doi: 10.1016/j.jep.2009.06.007

Rasik AM, Raghubir R, Gupta A, Shukla A, Dubey MP, Srivastava S, et al.. Healing potential of Calotropis procera on dermal wounds in Guinea pigs. J Ethnopharmacology. 1999;68(1–3):261–6.

Descargas

Publicado

2018-03-20

Cómo citar

1.
Bairagi SM, Ghule P, Gilhotra R. Farmacología de productos naturales: un enfoque reciente en Calotropis gigantea y Calotropis procera. Ars Pharm [Internet]. 20 de marzo de 2018 [citado 20 de noviembre de 2024];59(1):37-44. Disponible en: https://revistaseug.ugr.es/index.php/ars/article/view/7276

Número

Sección

Artículos de revisión