Nuevas perspectivas en el tratamiento de la diarrea aguda del lactante: racecadotrilo

Autores/as

  • J MALDONADO Departamento de Pediatría, Area de Gastroenterología y Nutrición. Facultad de Medicina

Palabras clave:

Diarrea aguda, Antidiarreicos, Antisecretores intestinales, Racecadotrilo, Lactante, Niño

Resumen

El propósito del presente trabajo es realizar una puesta al día del tratamiento de la diarrea aguda del lactante, asícomo evaluar la efi cacia del racecadotrilo, un nuevo fármaco antisecretor intestinal, en el tratamiento de la diarreaaguda. Se revisan los datos disponibles en la bibliografía referentes al tratamiento de rehidratación y realimentacióny sobre racecadotrilo, en este último caso tanto en experimentación animal como sobre el tratamiento de adultos yniños afectos de diarrea aguda. Los resultados obtenidos ponen de manifi esto que la administración de racecadotriloen lactantes y niños es segura y bien tolerada y que disminuye la duración y la severidad de la diarrea.

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Citas

Farthing MJG. Diarrhoea: a significat wordwide problem. Int J Antimicrob Agents 2000; 14: 65 – 69.

Farthing MJG. Acute diarrhea: pathophysiology. In: Gracey M, Walker-Smith JA, eds. Diarrheal disease. Nestlé Nutrition Worshop Series, vol. 38. Vevey: Nestec Ltd / Philadelphia: Lippincott-Raven, 1997; p 55 – 73.

Cohen MB, Lancy DW. Diarrea infecciosa. En: Wyllie R, Hyams JS, eds. Gastroenterología pediátrica. México: McGraw-Hill Interamericana, 2001; p 395 – 419.

Hirschhorn N. The treatment of acute diarrhea in children: An historical and physiological perspective. Am J Clin Nutr 1980; 33: 637 – 663.

Booth I, Cunha-Ferreira R, Desjeux JF. Recommendations for composition of oral rehydration solutions for the children of Europe. Report of an ESPGAN working group. J Pediatr Gastroenterol Nutr 1992; 14: 113 – 115.

Fontaine O. Multicentre evaluation of reduced-osmolarity oral rehydration salts solution. International Study Group on Reduced-osmolarity ORS Solutions. Lancet 1995; 345: 282 – 285.

Armon K, Stephenson T, MacFaul R, Eccleston P, Werneke U. An evidence and consensus basewd guideline for acute diarrhoea management. Arch Dis Child 2001; 85: 132 – 142.

Guandalini S. Treatment of acute diarrhea in de new millennium. J Pediatr Gastroenterol Nutr 2000; 30: 480 – 489.

Molla M, Molla A. Cereal based oral rehydration in the treatment of diarrhea. In: Greacy M, Walker-Smith JA, eds. Diarrheal disease. Nestlé Nutrition Worshop Series, vol. 38. Vevey: Nestec Ltd / Philadelphia: Lippincott-Raven, 1997; p 125 – 138.

Gore JM, Fontaine O, Pierce NF. Impact on rice based oral rehydration solution on stool output and duration on diarrhea: meta-analysis of 13 clinical trials. BMJ 1992; 304: 287 – 291.

Bhan MK, Mahalanabis D, Fontaine O, Pierce NF. Clinical trials of improved oral rehydration salt formulations: a review. Bull World Health Organ 1994; 72: 945 – 955.

Desjeux JF. Can malabsorbed carbohydrates be useful in the treatment of acute diarrhea?. J Pedaitr Gastroenterol Nutr 2000; 31: 499 - 502.

Ronbeau JL, Kripke SC. Metabolic and intestinal effects of short-chain fatty acids. JPEN 1990; 14: 181S – 185S.

Alam NH, Meier R, Schneider H, Sarker SA, Bardhan PK, Mahalanabis D, et al. Partially hydrolyzed guar gumsupplemented

oral rehydration solution in the treatment of acute diarrhea in children. J Pediatr Gastroenterol Nutr 2000; 31: 503 – 507.

Suárez L. Gastroenteritis aguda: rehidratación oral y tratamiento nutricional. ¿Hacemos lo que debemos hacer?. An Esp Pediatr 2001; 55: 2 – 4.

Baker SS, Davis AM. Hypocaloric oral therapy during an episode of diarrhea and vomiting can lead to severe malnutrition. J Pediatr Gastroenterol Nutr 1998; 27: 1 – 5.

Walker-Smith JA, Sandhu BKIsilaeni E, Banchini G, van Caille-Bertrand M, Diaz JA, et al. Guidelines prepared by the ESPGAN Working Group on Acute Diarrhoea. Recommendations for feeding in childhood gastroenteritis. J Pediatr Gastroenterol Nutr 1997; 24: 619 – 620.

AAP. Provisional Committee on Quality Improvement, Subcommittee on Acute Gastroenteritis. Practice parameter: The management of acute gastroenteritis in children. Pediatrics 1996; 97: 424 – 433.

Brow KH, Peerson JM, Fontaine O. Use nonhuman milks in the dietary management of young children with acute diarrhea: a meta-analysis of clinical trials. Pediatrics 1994; 93: 17 – 27.

Sandhu BK, Isolauri E, Walker-Smith JA, Banchini G, van Caille-Bertrand M, Diaz JA, et al. A Multicentre study on behalf of ther European Society of Paediatric Gastroenterology and Nutrition. Working Group on Acute Diarrhea. Early feeding in childhood gastroenteritis. J Pediatr Gastroenterol Nutr 1997; 24: 523 – 527.

Rabbanik GH, Fuchs GJ, Teka T, Majid N, Khatun M, Fuchs GJ. Clinical studies in persistent diarrhea: dietary management with green banana or pectin in Bangladeshi children. Gastroenterology 2001; 121: 554 – 560.

Tormo R, Infante D, Bergadá A. Butyrate production in infants fed a hydrolised guar gum enriched lactose free formula. J Pediatr Gastroenterol Nutr 2001; 32: 204.

Guerrero J. Valoración crítica del tratamiento medicamentoso en la diarrea infecciosa. An Esp Pediatrt 1986; 25: 279 – 287.

van Niel CW, Feudtner C, Garrison MM, Christakis DA. Lactobacillus therapy for acute infectious diarrea in children: a meta-analysis. Pediatrics 2002; 109: 678 – 684.

Schwartz JC. Racecadotril: a new approach to the treatment of diarrhoea. Int J Antimicrob Agents 2000; 14: 75 – 79.

Turvill JL, Farthing MGJ. Enkephalins and enkephalinase inhibitors in intestinal fluid and electrolyte absorption. Eur J Gastroenterol Hepatol 1997; 9: 877 – 880.

Primi MP, Bueno L, Baumer O, Berard H, Lecomte JM. Racecadotril demostrated intestinal antisecretory activity in vivo. Aliment Pharmacol Ther 1999; 13 (suppl 6): 3 – 7.

Duval-Ifah Y, Berard H, Baumer P, Guillaume P, Ribaud p, Joulin Y, Lecomte JM. Effects of racecadotril and loperamide on bacterial proliferation and on the central nervous system of the newborn gnotobiotic piglet. Aliment Pharmacol Ther 1999; 13 (suppl 6): 9 – 14.

Hinterleitner TA, Petritsch W, Dimsity G, Berard H, Lecomte JM, Krejs GJ. Acetorphan prevents cholera-toxin-induced water and electrolyte secretion in the human jejunum. Eur J Gastroenterol Hepatol 1997; 9: 887 – 891.

Baumer P, Danquechin E, Bertrand J, Vetel JM, Schwartz JC, Lecomte JM. Effects of acetorphan, and enkephalinase inhibitor, on experimental and acute diarrhoea. Gut 1992; 33: 753 – 758.

Bergmann JF, Chaussade S, Couturier D, Baumer P, Schwartz JC, Lecomte JM. Effects of acetorphan, and antidiarrhoeal enkephalinase inhibitor, on oro-caecal and colonic transit times in healthy volunteers. Aliment Pharmacol Ther 1992; 6: 305 – 313.

Huijghebaert S, Awouters F, Tytgat GNJ. Racecadotril versus loperamide. Antidiarrheal research revisited. Dig Dis Sci 2003; 48: 239 – 250.

Lecomte JM. An overwied of clinical studies with racecadotril in adults. Int J Antimicrob Agents 2000; 14: 81 – 87.

Tiorfan®. Monografía del producto. Ferrer Internacional S.A. Barcelona.

Hamza H, Ben Califa H, Baumer P, Berard H, Lecomte JM. Racecadotril versus placebo in the treatment of acute diarrhoea in adults. Aliment Pharmacol Ther 1999; 13 (suppl. 6): 15 – 19.

Moraes E, Chinzon D, Coelho LG, Fernandes TF, Haddad MT, e Grupo Brasileiro de Pesquisa do Racecadotril. Estudo multicêntrico de grupos paralelos, randomizado, cego para o investigador, para avaliar a eficacia, segurança e tolerabilidade do racecadotril versus Saccharomices boulardii no tratamento da diarréia aguda em adultos. Rev Bras Med 2001, 58: 65 – 74.

Alam NH, Ashraf H, Khan WA, Karim MM, Fuchs GJ. Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial. Gut 2003; 52: 1419 – 1423.

Rogé J, Baumer P, Berard H, Schwartz JC, Lecomte JM. The enkephalinase inhibitor, acetorphan, in acute diarrhea: a double-blind controlled clinical trial versus loperamide. Scand J Gastroenterol 1993; 28: 352 – 354.

Vetel JM, Berard H, Fretault N, Lecomte JM. Comparison of racecadotril and loperamide in adults whit acute diarrhoea. Aliment Pharmacol Ther 1999; 13 (suppl 6): 21 – 26.

Prado D, the Global Adult Racecadotril Study Group. A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults. Scan J Gastroenterol 2002; 37: 656 – 661.

Hwang-Huei Wang, Ming-Jium Shieh, Kuan-Fu Liao. A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. World J Gastroenterol 2005; 11: 1540 – 1543.

Bhan MK, Bhatnagar S. Racecadotril-Is there enough evidence to recommended it for treatment of acute diarrhea?. Indian Pediatr 2004; 41: 12034 – 1204.

Salazar-Lindo E, Santisteban-Ponce J, Cheawoo E, Gutiérrez M. Racecadotril in the treatment of acute watery diarrhea in children. N Engl J Med 2000; 343: 463 – 467.

Cézard JP, Duhamel JF, Meyer M, Pharaan I, Brellaiche M, Maurage C, et al. Efficacy and tolerability of racecadotril in acute diarrhea in children. Gastroenterology 2001; 120: 799 – 805.

Turck D, Berard H, Fretault N, Lecomte JM. Comparison of racecadotril and loperamide in children with acute diarrhoea.

Aliment Pharmacol Ther 1999; 13 (suppl 6): 27 – 32.

Cojocaru B, Bouquet N, Timsit S, Wille C, Boursiqout C, Marcombes F, et al. Effect du racécadotril sur le recours aux soins dans le traitement des diarrhées aiguës du nourrison et de l´enfant. Arch Pédiatr 2002 ; 8 : 774 – 779.

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Publicado

2006-09-20

Cómo citar

1.
MALDONADO J. Nuevas perspectivas en el tratamiento de la diarrea aguda del lactante: racecadotrilo. Ars Pharm [Internet]. 20 de septiembre de 2006 [citado 26 de abril de 2024];47(3):251-63. Disponible en: https://revistaseug.ugr.es/index.php/ars/article/view/5037

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