Development and Evaluation of Moisturizing Cream containing Salvia hispanica and Aloe vera and its Antioxidant Potential

Rutuja K. Deore; Khemchand Surana; Sunil K. Mahajan; Rushikesh L. Bachhav; Deepak D. Sonawane

doi:10.30827/ars.v66i3.32785

Autores/as

Rutuja K. Deore Department of Pharmaceutical Quality Assurance, SSS’s Divine College of Pharmacy Satana, Nashik, Maharashtra
Khemchand Surana Department of Pharmaceutical Chemistry, Shreeshakti Shaikshanik Sanstha, Divine College of Pharmacy, Satana, Nashik, Affiliated to SavitribaiPhule Pune University, Pune, Maharashtra 423301, India
Sunil K. Mahajan Department of Pharmaceutical Chemistry, SSS’s Divine College of Pharmacy, Satana, Nashik, Maharashtra
Rushikesh L. Bachhav Department of Pharmaceutical Quality Assurance, SSS’s Divine College of Pharmacy Satana, Nashik, Maharashtra
Deepak D. Sonawane Department of Pharmaceutics, SSS’s Divine College of Pharmacy, Nashik, Maharashtra

DOI:

https://doi.org/10.30827/ars.v66i3.32785

Palabras clave:

Aloe vera, Salvia hispanica, Chia, Moisturizing cream, antioxidant

Resumen

Introducción: Los bioactivos presentes en las semillas de Salvia hispánica (chía) y el aloe vera hidratan, protegen y restauran la piel. El objetivo de este trabajo es formular y evaluar una crema herbal multifuncional con mucílago de semilla de Salvia hispánica, gel de aloe vera, manteca de karité y aceite de coco para hidratar y restaurar la piel.

Métodos: El extracto de semilla de Salvia hispánica se obtuvo mediante la extracción del mucílago. Se preparó gel de aloe vera y se incorporó a la fórmula junto con manteca de karité y aceite de coco. La fórmula final de la crema se evaluó en cuanto a parámetros fisicoquímicos como pH (6), extensibilidad (7,5 g/s), consistencia, lavabilidad y ausencia de irritación. Se realizó un ensayo de depuración de peróxido de hidrógeno para determinar la actividad antioxidante.

Resultados: La crema formulada demostró actividad antioxidante y reveló una significativa capacidad de eliminación de peróxido de hidrógeno del 95,16 %, lo que indica un alto potencial de eliminación de radicales. La formulación presentó características fisicoquímicas deseables.

Conclusión: Este estudio descubrió que la crema tiene actividad antioxidante con su composición natural y componentes vegetales beneficiosos, podría ser una solución eficaz y sostenible para el cuidado de la piel.

Descargas

Citas

Enes BN, Moreira LD, Toledo RC, Moraes ÉA, de Castro Moreira ME, Hermsdorff HH, Noratto G, Mertens-Talcott SU, Talcott S, Martino HS. Effect of different fractions of chia (Salvia hispanica L.) on glucose metabolism, in vivo and in vitro. J Funct Food. 2020;71:104026. Doi: 10.1016/j.jff.2020.104026 DOI: https://doi.org/10.1016/j.jff.2020.104026

Din ZU, Alam M, Ullah H, Shi D, Xu B, Li H, Xiao C. Nutritional, phytochemical and therapeutic potential of chia seed (Salvia hispanica L.). A mini-review. Food Hydrocoll Health. 2021;1:100010. Doi: 10.1016/j.fhfh.2021.100010

Güzel S, Ülger M, Özay Y. Antimicrobial and antiproliferative activities of chia (Salvia hispanica L.) seeds. Int J Sec. Meta. 2020;7(3):174-80. Doi: 10.21448/ijsm.722574 DOI: https://doi.org/10.21448/ijsm.722574

Lucas-González R, Roldán-Verdu A, Sayas-Barberá E, Fernández-López J, Pérez-Álvarez JA, Viuda-Martos M. Assessment of emulsion creams formulated with chestnut (Castanea sativa M.) flour and chia (Salvia hispanica L) oil as partial fat replacers in pork burger formulation. J Sci Food Agric. 2020; 100(3):1265-73. Doi: 10.1002/jsfa.10138 DOI: https://doi.org/10.1002/jsfa.10138

Ebrahim R, Abdelrazek A, El-Shora H, El-Bediwi AB. Effect of ultraviolet on molecular structure and photochemistry compounds for Salvia hispanica medical seeds. Egypt Acad J Biolog Sci. (D-Histology and histochemistry) 2022;14(1):127-35. Doi: 10.21608/eajbsd.2022.232507 DOI: https://doi.org/10.21608/eajbsd.2022.232507

Guiotto EN, Tomás MC, Haros CM. Development of highly nutritional breads with by-products of chia (Salvia hispanica L.) seeds. Food. 2020;9(6):819. Doi:10.3390/foods9060819 DOI: https://doi.org/10.3390/foods9060819

Oteri M, Bartolomeo G, Rigano F, Aspromonte J, Trovato E, Purcaro G, Dugo P, Mondello L, Beccaria M. Comprehensive chemical characterization of chia (Salvia hispanica L.) seed oil with a focus on minor lipid components. Food. 2022;12(1):23.Doi: 10.3390/foods12010023 DOI: https://doi.org/10.3390/foods12010023

Motyka S, Koc K, Ekiert H, Blicharska E, Czarnek K, Szopa A. The current state of knowledge on Salvia hispanica and Salviae hispanicae semen (chia seeds). Mole. 2022;27(4):1207.doi:10.3390/molecules27041207 DOI: https://doi.org/10.3390/molecules27041207

Banan ZM, Yaghobfar A, Mojab F. The chemical composition of Salvia macrosiphon seed. Iran J Pharm Sci. 2023;19(2):166-75. Doi: 10.22037/ijps.v19i2.43809

Dziadek K, Kopeć A, Dziadek M, Sadowska U, Cholewa-Kowalska K. The changes in Phytochemical compounds and antioxidant activity of chia (Salvia hispanica L.) herb under storage and different drying conditions: A comparison with other species of sage. Mole. 2022;27(5):1569. Doi: 10.3390/molecules27051569 DOI: https://doi.org/10.3390/molecules27051569

Madaan R, Bala R, Zandu SK, Singh I. Formulation and characterization of fast dissolving tablets using Salvia hispanica (chia seed) mucilage as superdisintegrant. Acta Pharm Sci. 2020;58(1):69-82. Doi: 10.23893/1307-2080.APS.05805

Saleh HE, Chiad JS, Shawkat SM. Extraction, Characterization, and Evaluation the Activity of Chia Seed (Salvia hispanica L.) as an Antibacterial for the Treatment of Gingivitis. Iraqi J Industr Res. 2022;9(3):110-8. Doi: 10.53523/ijoirVol9I3ID216 DOI: https://doi.org/10.53523/ijoirVol9I3ID216

Ramakrishna S, Gopikrishna UV. Formulation and Evaluation of Herbal Hair Cream. SchInt J Tradit Complement Med. 2022; 5(2):28-32. Doi: 10.36348/ssijtcm.2022.v5i02.002 DOI: https://doi.org/10.36348/sijtcm.2022.v05i02.002

Kulkarni AT, Agarkar BS, Sawate AR, Kshirsagar RB. Determination of physicochemical properties of chia seeds (Salvia hispanica L.). J Pharmacogn Phytochem. 2020;9(2):1858-61. Doi: NA

Sonawane PR, Sonawane SN, Aher SN, Surana KR, Patil VR, Mahajan SK, Patil DM. In silico Evaluation of Anti-Inflammatory Potential of Pyrimidine based Molecules. Adv Biores. 2024;15(4):196-207. Doi: 10.15515/abr.0976-4585.15.4.197206

Surana KR, Jadhav PS, Shewale HS, Wagh DB, Mahajan SK, Musale JV. Insilico and Biological Evaluation of Anti-Inflammatory Activity of synthesized Benzimidazoles Derivatives. Biosci Biotechnol Res Asia. 2024;20(3):1241-53. Doi: 10.13005/bbra/330 DOI: https://doi.org/10.13005/bbra/3300

Fakir JS, Ahire CM, Surana KR, Kalam A, Ahamad AA, Davanage MD. Formulation and Evaluation of Antibacterial and Anti-Inflammatory Emulgel Containing Eugenia caryophyllus Buds Extract. Biosci Biotechnol Res Asia. 2024;21(3):1183-96.Doi: 10.13005/bbra/3296. DOI: https://doi.org/10.13005/bbra/3296

Li J, Fan G, Chen Y, Luo J, Zhang R. Optimization and characterization of antioxidant-rich cream incorporating Aloe vera gel. J Cosmet Dermatol. 2023;22(2):221-228. Doi: 10.1111/jocd.15267 DOI: https://doi.org/10.1111/jocd.15267

Din ZU, Alam M, Ullah H, Shi D, Xu B, Li H, Xiao C. Nutritional, phytochemical and therapeutic potential of chia seed (Salvia hispanica L.). A mini-review. Food Hydrocoll Hlth. 2021;1:100010 Doi: 10.1016/j.fhfh.2021.100010 DOI: https://doi.org/10.1016/j.fhfh.2021.100010

Guzel KS, Ulger M, Kahraman A. Phytochemical analysis, antioxidant and antimicrobial activities of Salvia virgata mericarps. Bot Serb. 2021;45(2):223-31. Doi: 10.2298/BOTSERB2301019G DOI: https://doi.org/10.2298/BOTSERB2102223G

Madaan R, Bala R, Zandu SK, Singh I. Formulation and characterization of fast dissolving tablets using Salvia hispanica (chia seed) mucilage as superdisintegrant. Acta Pharm. Sci. 2020;58(1):69-82. Doi: 10.23893/1307-2080.APS.05805 DOI: https://doi.org/10.23893/1307-2080.APS.05805