Los extractos de Albizia julibrissin y Caesalpinia decapetala inducen la inhibición potencial de enzimas y el crecimiento celular a través de la actividad antiacetilcolinesterasa, antilipasa, antiglicación y citotoxicidad

Autores/as

  • Iram Fatima Department of Biotechnology, Fatima Jinnah Women University, Rawalpindi
  • Naila Safdar Department of Biotechnology, Fatima Jinnah Women University, Rawalpindi
  • Razia Kalsoom 2PCSIR Labs Complex, Plot no. 16, Sector H-9, Islamabad
  • Wasim Akhtar Department of Botany, University of Azad Jammu and Kashmir, Muzaffarabad
  • Syed Hussain Imam Abidi Pakistan Council of Scientific and Industrial Research (PCSIR), Head Office, 1-Constitution Avenue, G-5/2 Islamabad
  • Samia Akmal Department of Biotechnology, Fatima Jinnah Women University, Rawalpindi
  • Gul-e-Saba Chaudhry Institute of Climate Adaptation and marine Biotechnology, Universiti Malaysia Terengganu, 21030, Kuala Terengganu https://orcid.org/0000-0002-4555-8572

DOI:

https://doi.org/10.30827/ars.v66i3.32202

Palabras clave:

Cáncer; Enzimas; lipasa; Glucosilación; Cromatografía líquida de alta resolución; Productos naturales

Resumen

Introducción: Las plantas medicinales son una fuente dinámica de salud humana debido a su potencial terapéutico en el tratamiento de diversas dolencias. Este estudio tuvo como objetivo determinar las actividades antiacetilcolinesterasa, antilipasa, antiglicación y anticancerígena de Albizia julibrissin y Caesalpinia decapetala. (family Fabaceae).

Métodos: Los extractos de hojas se prepararon para investigar sus capacidades inhibitorias contra la acetilcolinesterasa, la lipasa y los productos de glicación. El potencial anticancerígeno se evaluó contra las líneas celulares HeLa, PC3 y 3T3 utilizando el ensayo MTT y se realizó un análisis HPLC para cuantificar seis compuestos.

Resultados: Los resultados indicaron la mayor actividad anti-acetilcolinesterasa (IC50 2,391 µg/ml) en el extracto metanólico de A. julibrissin, mientras que la mayor actividad anti-lipasa (114,9 µg/ml) y anti-glicación (43,69 µg/ml) se registró en el extracto metanólico de C. decapetala. El mayor potencial citotóxico también se observó en C. decapetala contra las líneas celulares PC3, 3T3 y HeLa. (144,3 ppm, 201,0 ppm and 236,0 ppm). Al final, la HPLC mostró que A. julibrissin exhibe la mayor concentración de ácido clorogénico (56,06 ppm) y dihidrato de quercetina (15,71 ppm), mientras que los extractos de hojas de C. decapetala poseen la mayor concentración de ácido gálico. (73,55 ppm).

Conclusiones: Los resultados sugieren que estos extractos inhiben significativamente las actividades enzimáticas, los productos de glicación y el crecimiento de células citotóxicas y, por lo tanto, pueden ser utilizados como nuevos compuestos farmacológicos para tratar diversas enfermedades.

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20-06-2025

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1.
Fatima I, Safdar N, Kalsoom R, Akhtar W, Imam Abidi SH, Akmal S, Chaudhry G- e-S. Los extractos de Albizia julibrissin y Caesalpinia decapetala inducen la inhibición potencial de enzimas y el crecimiento celular a través de la actividad antiacetilcolinesterasa, antilipasa, antiglicación y citotoxicidad. Ars Pharm [Internet]. 20 de junio de 2025 [citado 18 de julio de 2025];66(3):349-60. Disponible en: https://revistaseug.ugr.es/index.php/ars/article/view/32202

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