Identificación y caracterización de herramientas para evaluar la alergia a las penicilinas: Revisión estructurada

Autores/as

  • Liliana Marcela Osorio-Tapiero Universidad de Antioquia, Grupo de Investigación Promoción y Prevención Farmacéutica https://orcid.org/0000-0003-4567-1310
  • Pedro Amariles Universidad de Antioquia, Medellín https://orcid.org/0000-0002-3825-8045
  • Hector Holguín Clínica Medellín. Grupo Quirónsalud
  • Andrea Salazar-Ospina Universidad de Antioquia, Medeillín
  • Milena Ortiz Rendón Universidad de Antioquia, Medellín

DOI:

https://doi.org/10.30827/ars.v65i2.29840

Palabras clave:

Alergia penicilinas, pruebas cutáneas, pruebas de provocación oral, antibióticos betalactámicos

Resumen

Introducción: Las reacciones alérgicas son uno de los problemas de seguridad más graves asociadas al uso de medicamentos, siendo la alergia a los antibióticos betalactámicos la más prevalente. Las pruebas de alergia a las penicilinas pueden ayudar a identificar pacientes hospitalizados y ambulatorios que podrían tolerar y usar de manera segura este grupo de antibióticos y evitar rótulos que limiten el uso de antibióticos betalactámicos por tiempo indefinido.

Objetivo: Identificar las herramientas disponibles en la literatura para valorar el antecedente de alergia a las penicilinas y proponer una herramienta que consolide la información extraída.

Metodología: Revisión estructurada en PubMed/MEDLINE entre 1 junio 2015 hasta 30 noviembre 2022, utilizando los términos MeSH: (((“skin tests”[MeSH Terms]) OR (“skin irritancy tests”[MeSH Terms])) AND (“penicillins”[All Fields])) AND (“drug hypersensitivity”[MeSH Terms]). Publicaciones en inglés y español con acceso a texto completo y estudios realizados en humanos, sobre herramientas disponibles para evaluar la alergia a penicilinas fueron incluidos. 

Resultados: Se identificaron 201 artículos, de los cuales se incluyeron 108. Dentro de las herramientas para evaluar la alergia a las penicilinas se identificaron: a) pruebas in vivo: pruebas cutáneas, pruebas de provocación oral, pruebas del parche; y b) pruebas in vitro: pruebas de IgE específica, determinación de triptasa, histamina. De los 1181 pacientes reportados con alergia a las penicilinas, sólo el 2 % de ellos se confirmó la presencia de alergia. 

Conclusión: Las pruebas cutáneas y de provocación oral sumado a algunas combinaciones in vivo/in vitro, fueron las herramientas más utilizadas para evaluar la alergia a las penicilinas. 

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Citas

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2024-03-20

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Osorio-Tapiero LM, Amariles P, Holguín H, Salazar-Ospina A, Ortiz Rendón M. Identificación y caracterización de herramientas para evaluar la alergia a las penicilinas: Revisión estructurada . Ars Pharm [Internet]. 20 de marzo de 2024 [citado 2 de mayo de 2024];65(2):159-77. Disponible en: https://revistaseug.ugr.es/index.php/ars/article/view/29840

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