Identification of promoters in trypanosomes

Autores/as

  • M.B. MCANDREW

Palabras clave:

Trypanosomas, Transcription, control post-transcriptional, promotores

Resumen

The trypanosomes diverged early in eukaxYotíc evolution, reflected in the existence of many unusual biological features such as polycistronic transcription and antigenic variation. The mechanisms by which genes are expressed has been an area of intensive study over the last two decades and some of the peculiar aspects of gene expression are briefly discussed. Promoters for RNA polymerase 11 have eluded detection in these organisms and in their absence, an in vitro system which would permit the dissection of transcription cannot be established. Here, 1 concentrate on the search for promoters with particular reference to an approach recently used to isolate them from Trypanosoma brucei

Descargas

Los datos de descargas todavía no están disponibles.

Citas

LAYTON, e .E.: Prog Nuc/eic Acids Res Mol Biol (1992), 43:37-66.

VANHAMME, L., PAYS, E.: Microbiol Rev (1995), 59:223-240.

GOTTESDIENER, K., GAReíA-ANOVEROS, J., LEE, M. G., VAN DER PLOEG, L. H.: Mol Cell Biol (1990), 10:6079-83.

WHITE, T. e ., RUDENKO, G., BORST, P.: Nuc/ Acids Res (1986), 14:9471-9480.

JANZ, L., eLAYTON, e.: Mol Cell Biol (1994), 14:5804-5811.

PAYS, E.: Symp Soc Gen Microbiol (1993), 50:127-160.

KOOTER, J. M., BORST, P.: Nuc/eic Acids Res (1984), 12:9457-9472.

PAYS, E., eOQUELET, H., TEBABI, P., PAYS, A., JEFFERIES, D., STEINERT, M., KOENIG, E., WILLIAMS, R. O., RODITI, 1.: EMBO J (1990), 9:3 145-51.

RUDENKO, G., LEE, M. G., VAN DER PLOEG, L. H.: Nuc/eic Acids Res (1992), 20:303-6.

LAYTON, e . E., FUERI, J. P., ITZAHKI, J. E., BELLOFATTO, V., SHERMAN, D. R., WISDOM, J. E., VIJAYSARATHY, S., MOWATT, M. R. : Mol Ce/l Biol (1990), 10:3036-3047.

GRAHAM, S. V., BARRY, J. D.: Mol Biochem Parasitol (1991), 47:3 1-42.

GRONDAL, E. J. M., EVERS, R., KOSUBEK, eORNELISSEN, K. ,AND A. W. S. A.: EMBO J (1991), 8:3383-3389.

SHERMAN, D. R., JANZ, L., HUG, M., eLAYTON, e .: EMBO J (1991), 10:3379- 3386.

BROWN, S. D., HUANG, 1., VAN DER PLOEG, L. H.: Mol Cell Biol (1992), 12:2644-52.

LA YTON, c.: Personal cornrnunication.

EVERS, R., HAMMER, A., KÓeK, J., JESS, W., BORST, P., MÉMET, S., eORNELISSEN, A. W. e. A.: Cell (1989), 56:585-597.

SMITH, J. L., LEVIN, J. R., INGLES, e . J., AGABIAN, N.: Cell (1989), 56:815-27.

MOTTRAM, J., PERRY, K. L., LIZARDI, P. M., LUHRMAN, R., AGABIAN, N.: Mol Ce/l Biol (1989), 9:1212-1223.

MOTTRAM, J. e ., BELL, S. D., NELSON, R. G., BARRY, J. D.: J Biol Chem (1991), 266:18313-18317.

NAKAAR, V., DARE, A. O., HONG, D., ULLU, E., TseHUDI, e .: Mol Cell Biol (1994), 14:6736-6742 .

BORST, P.: Annu Rev Biochem (1986), 55:701-732 .

NELSON, R. G., PARSONS, M., BARR, P. J., STUART, K., SELKIRK, M., AGABIAN, N.: Ce/l (1983), 34:901-9.

DORFMAN, D. M., DONELSON, J. E.: Nuc/eic Acids Res (1984), 12:4907-20.

SAlTO, R. M., ELGORT, M. G., eAMPELL, D. A. : EMBO J (1994), 13:303-306.

MATTHEWS, K. R., TseHUDI, e., ULLU, E.: Genes Dev (1994), 8:491-501.

LEBOWITZ, J. H., SMITH, H. Q., RUSeHE, L., BEVERLEY, S. M.: Genes Dev (1993), 7:996-1007.

Descargas

Publicado

1997-03-20

Cómo citar

1.
MCANDREW M. Identification of promoters in trypanosomes . Ars Pharm [Internet]. 20 de marzo de 1997 [citado 19 de mayo de 2024];38(2-3):245-57. Disponible en: https://revistaseug.ugr.es/index.php/ars/article/view/21159

Número

Sección

Artículos Originales