Molecular mechanism of drug resistance in parasites

Authors

  • F. Gamarro
  • S. Castanys

Abstract

Drug resistance is a multifactorial process involving different coexistent mechanisms, among them: modifications of drug entry, intracellular inactivation of drug, amplification of genes coding for target proteins or proteins involved in drug efflux, mutations in target proteins and increased repair of cell damage. Last years, our research group has been involved in the study of drug resistant mechanisms in the protozoan parasites Leishmania (L. tropica y L. infantum) and Trypanosoma cruzi. Our focus has been related with the study of transporters inc1uded in the superfamily ABC (ATP-binding cassette), specifically the P-glycoproteins involved in efflux of drugs and xenobiotics. Molecular and functional studies of these mechanisms, will help significantly the development of treatment alternative strategies to use in case of drug resistance in parasites.

Downloads

Download data is not yet available.

References

( 1) GAMARRO, F. Y CASTANYS, S.: En: Parasitología Molecular (1993) CSIC .Nuevas Tendencias vol 24, pp 113-134, eds. L. Rivas y M. C. López, Madrid.

(2) FERONE, R.: J Biol Chem (1970), 245:850-854.

(3) CHIQUERO, M. J., PÉREZ-VICTORIA, J. M., O'VALLE, F., GONZÁLEZ-ROS, J. M., DEL MORAL, R. G., FERRAGUT, J. A., CASTANYS, S. y GAMARRO, F.: Biochem Pharmacol (sometido).

(4) ESCRIBA, V. P., FERRER-MONTIEL, A. V., FERRAGUT J.A. y GONZÁLEZ-ROS, 1. M.: Biochemistry (1990), 29:7275-7282.

(5) GAMARRO, F., CHIQUERO, M. J., AMADOR, M. V., LÉGARÉ, D., OUELLETTE, M. Y CASTANYS, S.: Biochem Pharmacol (1994), 47:1939-1947.

(6) HIGHTOWER, R. C., RUIZ-PÉREZ, L.M., WONG, M. L. Y SANTI, D. V.: J BiolChem (1988), 263:16970-16976.

(7) CHIQUERO, M. J., OLMO, A., NAVARRO, P., RUIZ-PÉREZ, L. M., CASTANYS, S., GONZÁLEZ-PACANOWSKA, D., y GAMARRO, F.: Biochim Biophys Acta ( 1994), 1227:188-194.

Downloads

Published

1997-03-20

How to Cite

1.
Gamarro F, Castanys S. Molecular mechanism of drug resistance in parasites . Ars Pharm [Internet]. 1997 Mar. 20 [cited 2024 May 19];38(2-3):137-49. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21088

Issue

Vol. 38 No. 2-3 (1997)

Section

Original Articles

License

The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:

  1. The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.

b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.

c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).