Contenido principal del artículo

Dr.Tapas Kumar Sur Sur
Research Scientist II, Multidisciplinary Research Unit, R.G. Kar Medical College, 1 Khudiram Bose Sarani, Kolkata 700004, West Bengal, India
India
https://orcid.org/0000-0003-0835-2564
Avijit Hazra
Department of Pharmacology, Institute of Post Graduate Medical Education & Research, Kolkata
India
Dipankar Bhattacharyya
Department of Pharmacology, Institute of Post Graduate Medical Education & Research, Kolkata
India
Alok Kumar Hazra
RKM Vivekananda Educational & Research Institute, Kolkata
India
Vol. 62 Núm. 4 (2021), Artículos Originales, Páginas 348-357
DOI: https://doi.org/10.30827/ars.v62i3.20759
Recibido: Mar 5, 2021 Aceptado: May 5, 2021 Publicado: Sep 20, 2021
Derechos de autor Cómo citar

Resumen

Introducción: Sonneratia apetala Buch-Ham es un verdadero habitante de los manglares en Sunderban indio y se utiliza en la medicina popular para los trastornos digestivos.


Método: El extracto hidrometanólico (20:80) de hojas de Sonneratia apetala (SA) se estandarizó químicamente por HPTLC y se evaluó por sus propiedades antirradicales y gastroprotectoras. Se determinaron los fenólicos y flavonoides presentes en SA y se evaluaron las actividades antirradicales mediante métodos in vitro como, DPPH (1,1-difenil-2-picrilhidrazilo), óxidos nítricos, superóxidos, hidroxilo y ABTS (2,2 / -azino-bis- Ácido 3-etilbenztiazolin-6-sulfónico). Además, se evaluó la eficacia gastroprotectora de SA en la ulceración oxidativa inducida por alcohol (50% v / v, 5 ml / kg) en ratas.


Resultados: El SA químicamente estandarizado mostró presencia de compuestos polifenólicos. También mostró fuertes propiedades antirradicales. Las administraciones orales de SA (125 mg / kg y 250 mg / kg) protegieron significativamente la membrana mucosa gástrica del daño ulcerativo causado por el alcohol, similar al omeprazol (20 mg / kg) en ratas. Además, el tratamiento con SA redujo significativamente la elevación de los peróxidos de lípidos; mientras que aumentó la concentración de glutatión y catalasa en la mucosa gástrica con respecto a las ratas de control no tratadas inducidas por etanol.


Conclusiones: Los resultados obtenidos de este estudio sugieren que la hoja de Sonneratia apetala tiene propiedades antioxidantes y tiene capacidad para proteger la lesión de la mucosa gástrica causada por la ingestión de alcohol.

Descargas

La descarga de datos todavía no está disponible.

Detalles del artículo

Citas

Spalding M, Kainuma M, Collins L. World atlas of mangroves. Earthscan: London, 2010.

Mandal RN, Naskar KR. Diversity and classification of Indian mangroves: a review. Trop Ecol. 2008; 49:131-146.

Wu SB, Wen Y, Li XW, Zhao Y, Zhao Z, Hu JF. Chemical constituents from the fruits of Sonneratia caseolaris and Sonneratia ovata (Sonneratiaceae). Biochem Syst Ecol. 2009; 37:1-5. Doi: 10.1016/j.bse.2009.01.002

Bandaranyake WM. Traditional and medicinal uses of mangroves. Mang Salt Marsh.1998; 2:133-148. Doi:10.1023/A:1009988607044

Charoenteeraboon J, Wetwitayaklung P, Limmatvapirat C, Paechamud T. Hepatoprotective activity from various parts of Sonneratia caseolaris. Planta Med. 2007; 73:561-565.

Ali M, Muhit M, Goshwami D, Masud M, Begum B. Antioxidant, cytotoxic and antimicrobial activity of Sonneratia alba barks. Int J Pharm Sci Res. 2012; 3:2233-2237. Doi: 10.13040/IJPSR.0975-8232.3(7).2233-37

Majumdar SG, Patra G. Chemical investigation of some mangrove species. Part VI. Sonneratia apetala. J Indian Chem Soc. 1979; 56:218.

Jiny VK, Belzik N, Nisha AR, Resiya S, Resmi S, Silvipriya KS. Pharmacognostical and phytochemical studies of a mangrove (Sonneratia caseolaris) from Kochi of Kerala state in India. J Pharm Res. 2010; 3:2625.

Sadhu S K, Ahmed F, Ohtsuki T, Ishibashi M. Flavonoids from Sonneratia caseolaris. J Nat Med.2006; 60:264-265. Doi:10.1007/s11418-006-0029-3

Popovic M, Janicijevic HS, Kaurinovic B, Rasic J, Trivic S. Antioxidant effects of some drugs on ethanol-induced ulcers. Molecules. 2009; 14:816-826. Doi:10.3390/molecules14020816

Sumbul S, Ahmad A, Asif M, Akhtar M. Role of phenolic compounds in peptic ulcer: An overview. J Pharm Bioallied Sci. 2011; 3:361-367. Doi:10.4103/0975-7406.84437

Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals. 8th ed. The National Academic Press: Washington DC., 2008.

Harbone JB, Phytochemical methods. 2nd ed., Chapman and Hall: London, 2002.

Sur TK, Hazra AK, Bhattacharyya D, Hazra A. Antiradical and antidiabetic properties of standardized extract of Sunderban mangrove Rhizophora mucronata. Pharmacog Res. 2015; 11:389-394. Doi:10.4103/0973-1296.153094

Banerjee D, Hazra AK, Seal T, Sur TK, Bhattacharyya D, Ray J, Mukherjee A, Mukherjee B. Antioxidant and anti-inflammatory activities of different solvent extracts and isolated compounds of Ipomoea pes-caprae (L) sweet of Sunderban mangrove eco-complex. Asian J Chem. 2013; 25:4997-5000.

Sur TK, Hazra A, Hazra AK, Bhattacharyya D. Antioxidant and hepatoprotective properties of Indian Sunderban mangrove Bruguiera gymnorrhiza L. leave. J Basic Clin Pharm. 2016; 7(3): 75-79. Doi: 10.4103/0976-0105.183262

Morimoto Y, Shimohara K, Oshima S, Sukamoto T. Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine. Japanese J Pharmacol. 1991; 57:495. Doi:10.1254/jjp.57.495

Sur TK, Pandit S, Bhattacharyya D, Debnath PK. Antiulcer activity of Shankha Bhasma (calcinated conch shell). Explor Anim Med Res. 2013; 3:48-56.

Mousa AM, El-Sammad NM, Hassan SK, Madboli AENA, Hashim AN, Moustafa ES, Bakry SM, Elsayed EA. Antiulcerogenic effect of Cuphea ignea extract against ethanol-induced gastric ulcer in rats. BMC Complement Altern Med. 2019 Dec 2;19(1):345. Doi:10.1186/s12906-019-2760-9.

Pandit S, Sur TK, Jana U, Bhattacharyya D, Debnath PK, Anti-ulcer effect of Shankha Bhasma in rats: a preliminary study. Indian J Pharmacol. 2000; 32:378-380.

Lyle N, Gomes A, Sur TK, Munsi S, Paul S, Chatterjee S, Bhattacharyya D. Possible role of antioxidant property of Nardostachys jatamansi in alleviation of chronic fatigue syndrome. Behav Brain Res. 2009; 202:285-290. Doi: 10.1016/j.bbr.2009.04.005

Bhattacharyya D, Pandit S, Jana U, Sen S, Sur TK. Hepatoprotective activity of Adhatoda vasica aqueous leaf extract on D-galactosamine induced liver damage in rats. Fitoterapia. 2005; 76:223-225. DOI: 10.1016/j.fitote.2004.10.014

World Health Organization. Level of consumption. 2016. https://www.who.int/data/gho/data/themes/topics/topic-details/GHO/levels-of-consumption

World Health Organization. Global status report on alcohol and health. 2014. https://www.who.int/substance_abuse/publications/global_alcohol_report/

Tang Y, Forsyth CB, Farhadi A, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ, Keshavarzian A. Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage. Alcohol Clin Exp Res. 2009; 33:220-232. Doi: 10.1111/j.1530-0277.2008.00842.

Hajrezaie M, Salehen N, Karimian H, Zahedifard M, Shams K, Batran RA. Biochanin a gastroprotective effects in ethanol-induced gastric mucosal ulceration in rats. PloS One. 2015; 10:e01215291. Doi: 10.1371/journal.pone.0121529.

Mota KS, Dias GE, Pinto ME, Ferreira AL, Brito MS, Lima CA. Flavonoids with gastro-protective activity. Molecules. 2009; 14:979-1012. Doi:10.3390/molecules14030979.

Nordmann R. Alcohol and antioxidant systems. Alcohol. 1994; 29:513-522. Doi: 10.1093/oxfordjournals.alcalc.a045580