Clozapina: una visión histórica y papel actual en la esquizofrenia resistente al tratamiento

Autores/as

  • JJ ELIZONDO ARMENDÁRIZ Sección de Farmacia y Dietética. Clínica de Rehabilitación de Salud Mental. Avenida de Villava 53, 31015 Pamplona (Navarra)

Palabras clave:

Clozapina, Esquizofrenia resistente, Neutropenia, Agranulocitosis

Resumen

Clozapina fue desarrollado como el primer fármaco antipsicótico atípico con actividad frente a los síntomas tantopositivos como negativos de la esquizofrenia. Tras su retirada temporal debido a la aparición de algunos casos deagranulocitosis, fue reintroducido en el mercado (en España en 1993) en respuesta a la necesidad de disponer deuna alternativa para los casos de esquizofrenia resistente al tratamiento. Los resultados de los estudios ponen demanifi esto que clozapina representa el “gold standard” actualmente para el tratamiento de la esquizofrenia resistentey en los desórdenes psicóticos severos. El bajo riesgo de agranulocitosis y muerte que conlleva el uso de clozapina,siempre que se realice dentro de un programa de vigilancia, es compensado por los benefi cios clínicos del fármacoen el tratamiento de la esquizofrenia y de otros desórdenes neurológicos.

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Citas

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Publicado

2008-06-20

Cómo citar

1.
ELIZONDO ARMENDÁRIZ J. Clozapina: una visión histórica y papel actual en la esquizofrenia resistente al tratamiento. Ars Pharm [Internet]. 20 de junio de 2008 [citado 29 de marzo de 2024];49(2):135-44. Disponible en: https://revistaseug.ugr.es/index.php/ars/article/view/4917

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