Formulation and evaluation of ketoprofen loaded chitosan nanogel for pain management: <em>Ex-vivo</em> and <em>In-vivo</em> study

Inayat Bashir Pathan; Rashmi Dwivedi; Wahid Ambekar

doi:10.30827/ars.v60i2.8563

Autores/as

Inayat Bashir Pathan epartment of Pharmaceutics, Government College of Pharmacy, Aurangabad
Rashmi Dwivedi Department of Pharmaceutics, Government College of Pharmacy, Aurangabad
Wahid Ambekar Department of Pharmaceutics, Dr.VVPF’s College of Pharmacy, Ahmednagar

DOI:

https://doi.org/10.30827/ars.v60i2.8563

Palabras clave:

Parto transdérmico, ketoprofeno, nanogel

Resumen

Objetivo: El objetivo de este estudio fue desarrollar y evaluar un gel a base de nanoemulsión (nanogel) para el suministro transdérmico de ketoprofeno. Entre los diversos excipientes probados, se seleccionaron el ácido oleico, la mezcla de 80 y el etanol como aceite, surfactante y co-surfactante.

Métodos: La región de las nanoemulsiones se identificó mediante la construcción de diagramas de fase pseudoternarios utilizando la titulación de la fase acuosa. La nanoemulsión preparada se sometió a diferentes estudios de estabilidad termodinámica y la nanoemulsión que pasó las pruebas de estabilidad termodinámica se evaluó para determinar la viscosidad, el índice de refracción, el tamaño de las gotitas, la microscopía electrónica de transmisión y el estudio de permeación ex-vivo utilizando piel de cadáver humano

Resultados: Sobre la base de la evaluación, la formulación de C1, que consiste en 3.09% peso / peso de la fase oleosa, 60.54% peso / peso de S_mix y 36.36% peso / peso de agua destilada se seleccionaron como una formulación optimizada y se convirtieron a nanogel utilizando quitosano como Un agente gelificante. Nanogel se evaluó para estudio ex-vivo e in vivo. El nanogel mostró un aumento significativo en la actividad antiinflamatoria en comparación con el gel convencional.

Conclusión: En conclusión, el nanogel podría ser un sistema prometedor para mejorar la administración transdérmica del ketoprofeno.

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Citas

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