Aplicaciones terapéuticas de los probióticos

Autores/as

  • B ARRIBAS Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, España.
  • ME RODRÍGUEZ Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, España.
  • D CAMUESCO Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, España.
  • A ZARZUELO Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, España.
  • J GÁLVEZ Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, España.

Palabras clave:

Alimentos funcionales, Flora intestinal, Probióticos, Sistema inmune

Resumen

En los últimos años han comenzado a desarrollarse nuevos conceptos en nutrición como fruto de la preocupaciónpor una elevada calidad de vida de la sociedad desarrollada. Esto ha promovido la aparición del término “alimentofuncional”, que se puede defi nir como aquel producto, alimento modifi cado o ingrediente alimentario, que puedeproveer benefi cios a la salud superiores a los ofrecidos por los alimentos tradicionales. Las bacterias probióticasquedan incluidas dentro del campo de los alimentos funcionales, existiendo evidencias de su efi cacia en ciertas patologías,y sufi cientes estudios experimentales en otras para justifi car posibles mecanismos de acción que facilitenel desarrollo de microorganismos más efectivos, así como para defi nir los límites de su efectividad.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Suárez L, Perdomo M, Escobar H. Microflora bacteriana y ecosistema intestinal. Fisiopatología del intestino delgado contaminado. Diarrea aguda. Medio Ambiente en España. GEN 1994; 48 (2): 61-64.

Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, Wagendorp AA, Klijn N, Bindels JG, et al. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr 2000; 30: 61-67.

Fanaro S, Chierici R, Guerrini P, Vigi V. Intestinal microflora in early infancy: composition and development. Acta Paediatr 2003; 91(suppl.): 48-55.

Murch SH. Toll of allergy reduced by probiotics. Lancet 2001; 357: 1057-1059.

Guérin-Danan C, Andrieux C, Popot F, Charpilienne A, Vaissade P, Gaudichon C, et al. Pattern of metabolism and composition of the fecal microflora in infants 10 to 18 months old from day care centers. Am J Pediatr Gastroenterol 1997; 25: 281-289.

Sharma R, Schumacher U, Ronaasen V, Coates M. Rat intestinal mucosal responses to a microbial flora and different diets. Gut 1995; 36: 209-214.

Szentkuti L, Riedesel H, Enss ML, Gaertner K, Von Engelhardt W. Pre-epithelial mucus layer in the colon of conventional and germ-free rats. Histochem J 1990; 22: 491-497.

Maeda Y, Noda S, Tanaka K, Sawamura S, Aiba Y, Ishikawa H, et al. The failure of oral tolerance induction is functionally coupled to the absence of T cells in Peyer’s patches under germfree conditions. Immunobiology 2001; 204: 442-457.

Sansonetti PJ. War and peace at mucosal surfaces. Nat Rev Immunol 2004; 4: 953-964.

Diplock AT, Aggett PJ, Ashweel M, Bornet F, Fern EB, Roberfroid M. Scientif concepts of functional foods in Europe consensus documents. Br J Nutr 1991; 81: S1.

Cohendy, M. Description du ferment lactique puissant capable de s’acclimater dans l’intestine de l’homme. C. R. Soc. Biol. 1906b; 60: 558.

Tissier H. Traitement des infections intestinales par la méthode de transformation de la flore bactérienne de l’intestin. C R Soc Biol 1906; 359-361.

Vergio F. Anti-und Probiotika. Hipocrates 1954; 25: 116-119.

Lilly DM, Stillwell RH. Probiotics: growth promoting factors produced by microorganisms. Science 1965; 147: 747-748.

Fuller R. Probiotics in man and animals. J Appl Bacteriol 1989; 66: 365-367.

Ouwehand AC, Salminen S. The health effects of cultured milk products with viable and non-viable bacteria. Int Dairy J 1998; 8: 749-758.

Isolauri E, Kirjavainen PV, Salminen S. Probiotics – a role in the treatment of intestinal infection and inflammation. Gut 2002; 50: 54-59.

Shortt, C. „Living it up for dinner‰. Chemistry & Industry 1998; 8: 300-303.

Vaughan EE, de Vries MC, Zoetendal EG, Ben-Amor K, Akkermans ADL, de Vos WM. The intestinal LABs. Antonie van Leeuwenhoek 2002; 82: 341-352.

Le Blay G, Michel C, Blottiere HM, Cherbut C. Prolonged intake of fructooligosaccharides induces a short-term elevation of lactic acid-producing bacteria and a persistent increase in cecal butyrate in rats. J Nutr 1999; 129: 2231-2235.

Morrison DJ, Mackay WG, Edwards CA, Preston T, Dodson B, Weaver LT. Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate? Br J Nutr 2006; 96: 570-577.

Jack RW, Tagg JR, Ray B. Bacteriocins of Gram-positive bacteria. Microbiol Rev 1995; 59: 171-200.

Liévin V, Peiffer I, Hudault S., Rochat F, Brassart D, Neeser JR, et al. Bifi dobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity. Gut 2000; 47: 646-652.

Shida K, Takahashi R, Iwadate E, Takamizawa K, Yasui H, Sato T, et al. Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model. Clin Exp Allergy 2002; 32(4): 563-570.

Cummings JH. Short chain fatty acids in the human colon. Gut 1981; 22: 763-779.

Urao M, Fujimoto T, Lane GJ, Seo G, Miyano T. Does probiotic administration decrease serum endotoxin levels in infants?. J. Pediatr. Surg 1999; 34: 273-276.

Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003; 3: 31-41.

Rinne M, Kalliomaki M, Arvilommi H, Salminen S, Isolauri E. Effect of probiotics and breastfeeding on the bifi dobacterium and lactobacillus/enterococcus microbiota and humoral immune responses. J Pediatr 2005; 147: 186-191.

Ogawa T, Asai Y, Tamai R, Makimura Y, Sakamoto H, Hashikawa S, et al. Natural killer cell activities of symbiotic Lactobacillus casei ssp. casei in conjunction with dextran. Clin Exp Immunol 2006; 143:103-109.

Madsen KL, Doyle JS, Jewell LD, Tavernini MM, Fedorak RN. Lactobacillus species prevents colitis in interleukin 10 gene deficient mice. Gastroenterology 1999; 116: 1107-1114.

Haller D, Bode C, Hammes WP, Pfeifer AM, Schiffrin EJ, Blum S. Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut 2000; 47: 79-87.

Maassen CB, van Holten-Neelen C, Balk F, den Bak-Glashouwer MJ, Leer RJ, Laman JD, Boersma WJ, et al. Strain dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains. Vaccine 2000; 18: 2613-2623.

Morita H, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, et al. Adhesion of lactic acid bacteria to caco-2 cells and their effect on cytokine secretion. Microbiol Immunol 2002; 46: 293-297.

Lammers KM, Vergopoulos A, Babel N, Gionchetti P, Rizzello F, Morselli C, et al. Probiotic therapy in the prevention of pouchitis onset: decreased interleukin-1beta, interleukin-8, and interferon-gamma gene expression. Inflamm Bowel Dis 2005; 11: 447-454.

Ulisse S, Gionchetti P, D’Alo S, Russo FP, Pesce I, Ricci G, et al. Expression of cytokines, inducible nitric oxide synthase, and matrix metalloproteinases in pouchitis: effects of probiotic treatment. Am J Gastroenterol 2001; 96: 2691-2699.

Solis-Pereyra D, Aattouri N, Lemonnier D. Role of food in the stimulation of cytokine production. Am J Clin Nutr 1997; 66: 521S-525S.

Rangavajhyala N, Shahani KM, Sridevi G, Srikumaran S. Nonlipopolisaccharide component(s) of Lactobacillus acidophillus stimulate(s) the production of interleukin-1 alpha and tumor necrosis factor-alpha by murine macrophages. Nutr Cancer 1997; 28: 130-134.

Majamaa H, Isolauri E. Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol 1997; 99: 179-185.

Kirjavainen PV, El-Nezami HS, Salminen SJ, Ahokas JT, Wright PF. The effect of orally administered viable probiotic and dairy lactobacilli on mouse lymphocyte proliferation. FEMS Immunol Med Microbiol 1999; 26: 131-135.

Gill HS. Probiotics to enhance anti-infective defences in the gastrointestinal tract. Best Pract. Res. Clin. Gastroenterol 2003; 17: 755-773.

Marteau P, Shanahan F. Basic aspects and pharmacology of probiotics: an overview of pharmacokinetics, mechanisms of action and side-effects. Best Prac Res Clin. Gastroenterol 2003; 17: 725-740.

DeSimone C. The adjuvant effect of yogurt on gamma interferon by Con-A stimulated human lymphocytes. Nutr Rep Int 1986; 33: 419-433.

O’Sullivan MG, Thornton G, O’Sullivan GC, Collins JK. Probiotic bacteria: myth or reality. Trends Food Sci Technol 1992; 3: 309-314.

Del Miraglia GM, De Luca MG. The role of probiotics in the clinical management of food allergy and atopic dermatitis. J Clin Gastroenterol 2004; 38: S84-S85.

Tomioka H, Tomioka K, Sato K, Saito H. The protective activity of immunostimulants against Listeria monocytogenes infection in mice. J Med Microbiol 1992; 36: 112-116.

Walker WA. Role of nutrients and bacterial colonization in the development of intestinal host defense. J Pediatr Gastroenterol 2000; 30: S2-S7.

Marteau PR, de Vrese M, Cellier CJ, Schrezenmeir J. Protection from gastrointestinal diseases with the use of probiotics. Am J Clin Nutr 2001; 73: 430S-436S.

Saavedra J. Probiotics and infectious diarrhea. Am J Gastroenterol 2000; 95 (suppl.1): S16-S18.

Guandalini S. Probiotics for children: use in diarrhea. J Clin Gastroenterol 2006; 40: 244-248.

Hilton E, Kolakawaki P, Singer C, Smith M. Efficacy of Lactobacillus GG as a diarrhea preventive in travelers. J Travel Med 1977; 4: 41-43.

Floch MH, Hong-Curtiss J. Probiotics and functional foods in gastrointestinal disorders. Curr Gastroenterol Reports 2001; 3: 343-350.

Tabbers MM, Benninga MA. Administration of probiotic lactobacilli to children with gastrointestinal problems: there is still little evidence. Ned Tijdschr Geneeskd 2007; 151: 2198-2202.

Gaón D, García H, Winter L, Rodríguez N, Quintás R, González SN, et al. Effect of Lactobacillus strains and Saccharomyces boulardii on persistent diarrhea in children. Medicina 2003; 63: 293-298.

Descargas

Publicado

2008-03-20

Cómo citar

1.
ARRIBAS B, RODRÍGUEZ M, CAMUESCO D, ZARZUELO A, GÁLVEZ J. Aplicaciones terapéuticas de los probióticos. Ars Pharm [Internet]. 20 de marzo de 2008 [citado 28 de marzo de 2024];49(1):5-30. Disponible en: https://revistaseug.ugr.es/index.php/ars/article/view/5747

Número

Sección

Artículos de revisión