Contenido principal del artículo

J MIQUEL
Departamento de Biotecnología de la Universidad de Alicante. Campus de San Vicente del Raspeig
España
A RAMÍREZ-BOSCÁ
Departamento de Biotecnología de la Universidad de Alicante. Campus de San Vicente del Raspeig
España
Vol. 45 Núm. 2 (2004), Artículos de revisión, Páginas 91-109
DOI: https://doi.org/10.30827/ars.v45i2.5110
Recibido: Jul 22, 2016
Derechos de autor Cómo citar

Resumen

El aumento de la longevidad en los paises industrializados requiere costosos servicios sanitarios y asistenciales, puesmuchas personas ancianas sufren un proceso de envejecimiento patológico ligado a enfermedades degenerativascrónicas y déficits funcionales de larga duración. Por otra parte, numerosos estudios sugieren que más personaspodrían evitar el envejecimiento patológico si consumieran dietas ricas en antioxidantes. Así sería posible protegermás eficazmente al organismo contra el estrés oxidativo, que contribuye al envejecimiento normal y tiene un papelaún más importante en la aterosclerosis, la inmunodepresión y otros procesos degenerativos que a menudo formanparte del envejecimiento patológico.De acuerdo con lo anterior, y según los datos revisados, la suplementación de la dieta de los sujetos de edad madurao avanzada con antioxidantes (como la tioprolina, la N-acetilcisteina y los antioxidantes fenólicos de la cúrcuma)podría aumentar las probabilidades de prevenir o frenar los mencionados procesos degenerativos, ayudando así aconseguir una mayor longevidad con adecuada preservación funcional.

Descargas

La descarga de datos todavía no está disponible.

Detalles del artículo

Citas

Miquel J. Historical introduction to free radical and antioxidant biomedical research. En: Miquel J, Quintanilha AT, Weber

H. (Eds): CRC Handbook of Free Radicals and Antioxidants, vol.1. Boca Raton, FL: CRC Press; 1989. p. 3-13.

Bert P. Barometric Pressure: Researches in Experimental Physiology, 1878, translated by Hitchcock MA y Hitchcock FA.

Columbus: College Book Co; 1943.

Bean JW. Effects of oxygen at increased pressure. Physiol Rev 1945; 25: 1-4.

Bean JW. General effects of oxygen at high tension. En: Dickens F, Neil E (Eds): Oxygen in the Animal Organism. New

York: Pergamon Press; 1964. p. 455-461.

Raab O. Uber die Wirkung fluoresziender Stoffe auf Infusorien. Z Biol 1900; 39: 524-527.

Mulliken RS. Interpretation of the atmospheric absorption bands of oxygen. Physiol Rev 1929; 32: 880-883.

Michaelis L. Fundamental principles in oxido-reductions. Biol Bull 1949; 92: 2939-2941.

Gutteridge JMC, Westermarck T, Halliwell B. Oxygen radical damage in biological systems. En: Johnson JEJr, Walford

R, Harman D, Miquel J (Eds). Free Radicals, Aging and Degenerative Diseases. New York: Alan R Liss; 1986. p.99-

Singh A. Chemical and biochemical aspects of activated oxygen: singlet oxygen, superoxide anion, and related species.

En: Miquel J, Quintanilha AT, Weber H (Eds): CRC Handbook of Free Radicals and Antioxidants, vol 1. Boca

Raton,FL: CRC Press; 1989. p.17-28.

Nohl H, Hegner D. Do mitochondria produce oxygen radicals in vitro? Eur J Biochem 1978; 82: 563-567.

Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979; 59: 527-605.

Sato R, Omura T. Cytochrome P-450. New York: Academic Press; 1978.

Allen RC, Yevich SJ, Orth RW, Steele RH. The superoxide anion and singlet molecular oxygen, their role in the

microbicidal activity of the polymorphonuclear leucocyte. Biochem Biophys Res Comm 1974; 60: 909-917.

Klebanoff SJ. Oxygen metabolism and the toxic properties of phagocytes. Ann Intern Med 1980; 93: 480-487.

Porter NN. Prostaglandin endoperoxides. En: Pryor WA (Ed): Free Radicals in Biology, vol 4. New York: Academic

Press; 1986. p. 261-267.

Dam H, Granados GH. Peroxidation of body fat in vitamin E deficiency. Acta Physiol Scand. 1945; 10: 162-167.

Glavind J, Hartmann S, Clemmensens J, Jensen KE, Dam H. Studies on the role of lipoperoxides in human pathology.

II. The presence of peroxidized lipids in the arteriosclerotic aorta. Acta Pathol Microb Scand 1952; 30: 1-7.

Dubouloz F, Dumas J. Sur le metabolism des péroxides lipidiques dans le peau au cours des procésses “inflammatoires”.

Bull Soc Chem Biol 1954; 36: 983-986.

Dubouloz F, Dumas J. Sur le rôle des péroxides dans la genèse des lesions produits para les radiations. J Radiol Electrol

; 36: 343-350.

Slater TF. Free-radical mechanisms in tissue injury. Biochem J 1984; 222: 1-7.

Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. Cambridge: Clarendon Press; 1985.

Mukai FH, Goldstein BD. Mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated

fatty acids. Science 1976; 191: 868-871.

Ames BN. Dietary carcinogens and anticarcinogens. Science 1983; 221: 1256-1258.

Miquel J, Economos AC, Johnson JEJr. Mitochondrial role in cell aging. Exp Gerontol 1980; 15: 575-591.

Miquel J, Fleming JE. Theoretical and experimental support for an oxygen radical-mitochondrial damage hypothesis of

cell aging. En: Johnson JEJr., Harman D., Walford R., Miquel J. (Eds). Free Radicals, Aging and Degenerative

Diseases. New York: Alan R Liss; 1986. p. 51-74.

Miquel J. An update on the oxygen stress-mitochondrial mutation theory of aging: genetic and evolutionary implications.

Exp Gerontol 1998; 23: 113-126.

Miquel J. Envejecimiento celular y molecular: teorías del envejecimiento. En: Guillén F, Ruipérez I (Eds). Manual de

Geriatría, 3ª edición. Barcelona: Masson; 2002. p.29-42.

Miquel J. Estrés oxidativo en el envejecimiento y enfermedades degenerativas ligadas a la edad. Geriatrika 1996; 12:

-350.

Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11: 298-300.

Harman D. The aging process. Proc Nat Acad Sci USA 1981; 78: 7124-7128.

Gerschman R. Historical introduction to the “Free radical theory of oxygen toxicity.” En: Gilbert DL (Ed). Oxygen and

Living Processes: An Interdisciplinary Approach. New York: Springer Verlag; 1981. p. 44-46.

Vijg J, Müller WEG. The science of aging and the need for a mechanistic approach. Mech Ageing Dev 2000: 114: 1-3.

Sies H. Biochemistry of oxidative stress. Angew Chem 1986; 25: 1058-1071.

Williams GC. Pleiotropy, natural selection and the evolution of senescence. Evol-ution 1957; 2: 398-411.

Miquel J, Weber H. Aging and increased oxidation of the sulfur pool. En: Viña J (Ed). Glutathione: Metabolism and

Physiological Functions. Boca Raton, FL: CRC Press; 1990. p.187-192.

Dansette PM, Sassi A, Deschamps C. Sulfur containing compounds as antioxidants. En: Antioxidants in Therapy and

Preventive Medicine. Emerit I, Packer L, Auclair C (Eds). New York: Plenum Press; 1990. p. 209-215.

Miquel J, Blasco M. A simple technique for evaluation of vitality loss in aging mice, by testing their muscular

coordination and vigor. Exp Gerontol 1978; 13: 389-396.

Miquel J, Economos AC, Johnson JEJr. A systems analysis-thermodynamic view of cellular and organismic aging.

En: Johnson JEJr (Ed): Aging and Cell Structure, vol 2. Nueva York: Plenum Press; 1984. p. 247-380.

Viña JR, Sáez GT, Viña J. The physiological functions of glutathione. En: Miquel J, Quintanilha AT, Weber H (Eds):

CRC Handbook of Free Radicals and Antioxidants, vol. 2. Boca Raton, FL: CRC Press; 1989. p.121-132.

García de la Asunción J, Millán A, Pla R, Bruseghini I, Esteras A, Pallardó FV et al. Mitochondrial glutathione

oxidation correlates wth age associated oxidative damage to mitochondrial DNA. FASEB J 1996; 10: 333-338.

Sastre J, Pallardó FV, García de la Asunción J, Viña J. Mitochondria, oxidative stress and aging. Free Rad Res 2000;

: 189-198.

Pallardó EV, Asensi MJ, García de la Asunción J et al. Late onset administration of oral antioxidants prevents agerelated

loss of motor coordination and brain mitochondrial DNA damage. Free Rad Res 1998; 29: 617-623.

Miquel J, Ferrandiz ML, De Juan E, Sevila I, Martínez M. N-acetylcysteine protects against age-related decline of

oxidative phosphorylation in liver mitochondria. Eur J Pharmacol Env Toxicol. 1995; 292: 333-335.

Harding JJ, Blakytni R, Ganea E. Glutathione in disease. Biochem Soc Trans 1996; 24: 881-884.

Chen TS, Richie JPJr, Nagasawa HT, Lang CA. Glutathione monoethyl ester protects against glutathione deficiencies

due to aging and to acetoaminophen in mice. Mech Ageing Dev 2000; 120: 127-139.

Nagasawa HT, Goon DJW, Muldoon WP, Zera RT. 2-Substituted thiazolidine- 4 ( R) -carboxylic acids as prodrugs of

L-cysteine. Protection of mice against acetaminophen hepatotoxicity. J Med Chem 1984; 27: 591-596.

Abizanda Soler P, Luengo Márquez C. Arteriosclerosis, dislipemias, aneurismas, patología vascular periférica. En: F

Guillén Lera, I Ruipérez Cantera. Manual de Geriatría, 3ª Ed. Barcelona: Masson; 2002. p. 317-328.

Harman D. Atherosclerosis: oxidation of serum proteins and its relationship to pathogenesis. Clin Res 1960; 8: 108.

Kita T, Yokode M, Ishi K, Kume N, Nagano Y, Arai H et al. The role of oxidized lipoproteins in the pathogenesis of

atherosclerosis. Clin Exp Pharmacol Physiol 1992 ; 19(Suppl 20): 37-42.

Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H. Role of oxidative stress in atheroclerosis. Am J

Cardiol 2003; 91(3A): 7A-11A.

Sakurai K, Sawamuta T. Stress and vascular responses: endothelial dysfunction via lectin-like oxidized low-density

lipoprotein receptor-1: close relationships with oxidative stress. J Pharmacol Sci 2003; 91: 182-186.

Upston JM, Kritharides L, Stocker R. The role of vitamin E in atherosclerosis. Progr Lipid Res 2003; 42:405-422.

Norata GD, Pirillo A, Catapano AL. Statins and oxidative stress during atherogenesis. J Cardiovasc Dis 2003; 10: 181-

Kouoh F, Gressier B, Dine T, Luyckx M, Brunet C, Ballester L, et al. Antioxidant effects and anti-elastase activity of

the calcium antagonist nicardipine on activated human and rabbit neutrophils- a potential antiatherosclerotic property

of calcium antagonists? Cardiovasc Drugs Ther 2002; 16: 515-520.

Tamura K, Kato Y, Ishikawa A, Kato Y, Himori M, Yoshida M, et al. Design and synthesis of 4,6-Do-tert-butyl-

,3´dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.J Med Chem 2003; 46: 3083-3093.

Meng CQ. BO-653. Chugai. Curr Opin Investig Drugs 2003; 4: 342-346.

Glavind J, Hartmann S, Clemensen J, Jessen KE, Dam H. Studies on the role of lipid peroxide in human pathology. II. The presence of peroxidized lipids in the atherosclerotic aortas. Acta Pathol Microbio Scand 1952; 30: 1-17.

Yagi K, Ohkava H, Ohishi N, Yamashita M, Nakashima T. Lesions of aortic intima caused by intravenous administration of linoleic acid hydroperoxide. J Appl Biochem 1981; 3: 58-61.

Santos MT, Valles J, Aznar J. Plasma lipid peroxides in patients with vascular disease and in middle-aged normal subjects with a high risk of atherosclerosis. En: Miquel J, Quintanilha AT, Weber H (Eds). CRC Handbook of Free Radicals and Antioxidants, vol 1. Boca Raton, FL; CRC Press ;1989. p. 237-254.

Miquel J, Ramírez-Boscá A, Soler A, Díez A, Carrión-Gutiérrez MA, Díaz-Alperi J, Quintanilla-Ripoll E, Bernd A,

Quintanilla-Almagro E. Increase with age of serum lipid peroxides: implications for the prevention of atherosclerosis.

Mech Ageing Dev 1998; 100: 17-24.

Jialal I, Devaraj S, Kaul N. The effect of alpha-tocopherol on monocyte proatherogenic activity. Am J Clin Nutr 2001;

: 389S-394S.

O’Keefe JH, Lavie CJ, McCallister BD. Insights into the pathogenesis and prevention of coronary artery diseases. Mayo

Clin Proc 1995; 70: 69-79.

Fogelman AM, Shechter I, Seager J, Hokom M, Child JS, Edward PA. The metabolism of native and malonaldehydealtered

low density by human monocyte-macrophages. J Lip Res 1981; 22: 63-67.

Nagase M, Ando K, Nagase T, Kaname S, Sawamura T, Fujita T. Redox-sensitive regulation of lox-1 gene expression in vascular endothelium. Biochem Biophys Res Commun 2001; 281: 720-725.

Yokoyama M, Inoue N, Kawashima S. Role of the vascular NADH/NADPH oxidase system in atherosclerosis. Ann NY Acad Sci 2000; 902: 241-247.

Sorescu D, Szocs K, Griendling KK. NAD(P)H oxidases and their relevance to atherosclerosis. Trends Cardiovasc Med 2001; 11: 124-131.

Offerman MK, Medford RM. Antioxidants and atherosclerosis, a molecular perspective. Heart Dis Stroke 1994; 3: 52-57.

Holvoet P, Collen D. Oxidized lipoproteins in atherosclerosis and thrombosis. FASEB J 1994; 8: 1279-1284.

Yagi K. Serum lipid peroxides in subjects having certain diseases and aging. En: Miquel J, Quintanilha AT, Weber H (Eds). CRC Handbook of Free Radicals and Antioxidants, vol 1. Boca Raton, FL; CRC Press; 1989. p. 223-230.

Arteaga E, Rojas A, Villaseca P, Bianchi M, Arteaga A, Durán D. In vitro effect of estradiol, progesterone, testosterone, and of combined estradiol/progestins on low density lipoprotein (LDL) oxidation in postmenopausal women. Menopause 1998; 6: 16-23.

Signorelli SS, Neri S, Sciacchitano S, Di Pino L, Costa MP, Pennisi G, Ierna D, Caschetto S. Duration of menopause and behavior of malondialdehyde, lipids, lipoproteins and carotid wall artery intima-media thickness. Maturitas 2001; 39: 39-42.

Subbiah MT. Estrogen replacement therapy and cardioprotection: mechanisms and controversies. Braz J Med Biol Res 2002; 35: 271-276.

Meydani D. Dietary antioxidants modulation of aging and immune-endothelial cell interaction. Mech Ageing Dev 1999;123-132.

Jialal I, Vega GL, Grundig SM. Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein. Atherosclerosis 1990; 82: 185-191.

Goudev A, Kyurkchiev S, Gergova V, Karshelova E, Geeorgiev D, Atar D, Kehayov I, Nachev C. Reduced concentration of soluble adhesion molecules after antioxidants supplementation in postmenopausal women with high cardiovascular risk profiles-a randomised double blind study. Cardiology 2000; 94: 227-232.

Mesa MD, Ramírez-Tortosa MC, Aguilera CM, Ramírez-Boscá A, Gil A. Efectos farmacológicos y nutricionales de los extractos de Curcuma longa L. y de los curcuminoides. Ars Pharmaceutica 2003; 41: 307-321.

Witting PK, Petterson K, Östlund-Lindqvist A-M. et al. Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apoliprotein E and low density lipoprotein receptor gene double knockout mice. FASEB J 1999; 13: 667-675.

Meagher Treatment of atherosclerosis in the new millennium: is there a role for vitamin E? Prev Cardiol 2003; 6: 85-90.

Miquel J, Martínez, M. Díez, A, De Juan. E, Soler A, Ramírez, A, Laborda J, Carrión M. Effects of turmeric on blood and liver lipoperoxide levels of mice: lack of toxicity. Age 1995; 18: 171-174.

Ramírez-Boscá A, Carrión-Gutiérrez MA, Laborda Alvarez J, Quintanilla- Almagro E. Antioxidant curcuma extracts decrease the blood lipid peroxide levels of human subjects. Age 1995; 18: 167-169.

Ramírez-Boscá A, Carrión-Gutiérrez MA, Soler A, Puerta C, Díez A, Quintanilla E, Bernd A, Miquel J. Effects of the antioxidant turmeric on lipoprotein peroxides: implications for the prevention of atherosclerosis. Age 1997; 20: 165-168.

Ramírez-Tortosa MC, Mesa MD, Aguilera MC, Quiles L, Baro L, Ramírez- Tortosa CL, Martínez-Victoria C, Gil A. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Atherosclerosis 1999; 147: 371-378.

De la Fuente M, Victor VM. Anti-oxidants as modulators of immune function. Immunol Cell Biol 2000; 78: 49-54.

Suthantiran M, Anderson ME, Sharma UK, Meister A. Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via CD2 and CD3 antigens. Proc. Natl. Acad Sci USA 1990; 87: 3343-3347.

Ito Y, Kajkenova O, Feuers RJ, Udupa KB, Desai VG, Epstein J, Hart RW, Lipschitz DA. Impaired glutathione peroxidase activity accounts for the age-related accumulation of hydrogen peroxides in activated human neutrophils. J Gerontol 1998; M169-M175.

Tortorella C, Piazolla G, Spaccavento F, Jirillo E, Antonaci S. Age-related effects of oxidative metabolism and cyclic AMP signaling on neutrophil apoptosis. Mech Ageing Dev 1999; 110: 195-205.

Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med 2000; 28: 463-499.

De la Fuente M. Biología y envejecimiento: ¿dónde están los límites? En: J.M. Ribera Casado, P. Gil Gregorio (Eds). Prevención en Geriatría: ¿Es Posible?. Madrid: Edimsa; 2003. p. 23-42.

De la Fuente M. Papel de los antioxidantes en la nutrición del anciano. Rev Esp Geriatr Gerontol 2000; 35(S4): 63-71.

De la Fuente M, Ferrández MD, Burgos MS, Soler A, Prieto A, Miquel J. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 1998; 76: 373-380.

Stohs J, El-Rashid FH, Lawson T, Kobashi RH, Wulf BJ, Potter JF. Changes in glutathione and glutathione metabolizing enzymes in human erythrocytes and lymphocytes as a function of donor. Age 1984; 7: 3-7.

De la Fuente M, Miquel J. Efecto protector de antioxidantes tiólicos en la inmunodepresión asociada al envejecimiento. Rev Esp Geriatr Gerontol 1994; 29: 246-251.

Correa R, Blanco B, Del Río M, Victor V, Guayerbas N, Medina S. Effect of a diet supplemented with thioproline on murine macrophage function in a model of premature ageing. Biofactors 1999; 10: 195-200.

Miquel J. Can antioxidant diet supplementation protect against age-related mitochondrial damage? Ann N Y Acad Sci 2002; 959: 508-516.

Puerto M, Guayerbas N, Victor VM, De la Fuente M. Effects of N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing. Pharmacol Biochem Behav 2002; 73: 797-804.

Yu BP. Approaches to anti-aging interventions: the promises and the uncertainties. Mech. Ageing Dev 1999; 111: 73-87.